PMID: 9630045Jun 18, 1998Paper

HLA-DQB1 and DRB1 alleles in Egyptian children with steroid-sensitive nephrotic syndrome

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Ashraf M Bakr, F El-Chenawy

Abstract

Steroid-sensitive nephrotic syndrome (SSNS) of children has been associated with several HLA-DR and DQ alleles. To investigate this association in Egyptian children, 27 patients with SSNS were typed for HLA-DRB1 and DQB1 alleles using DNA polymerase chain-reverse hybridization technique. The results were compared with 121 healthy subjects for HLA-DRB1 and 59 subjects for DQB1 alleles. We found that: (1) patients have higher frequencies of both DQB1 *0601 (81.5% vs. 10.2% in controls, Pc=0.0001) and DRB1 *01 (44.4% vs. 3.3% in controls, Pc=0.00003). Their relative risks are significantly high [38.9, confidence interval (CI)=10.7-140.7, and 23.4, CI=6.7-81.9, respectively]; (2) the frequency of DRB1 *11 alleles was low in SSNS patients (3.75% vs. 32.2% in controls), but was not significant when P was corrected (P=0.005, Pc=NS). These findings suggest that DQB1 *0601 and DRBI *01 or closely associated unknown genes confer susceptibility to SSNS. However, further studies with larger numbers of patients are needed.

Citations

Dec 31, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ashraf M BakrFatma Al-Husseni
Sep 13, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aleksandra Krasowska-KwiecieńAnna Moczulska
May 16, 2012·Nephron. Clinical Practice·Bugsu OvuncUNKNOWN Gesellschaft für Pädiatrische Nephrologie (GPN) Study Group
Dec 4, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M Gibert, A Sanchez-Mazas
Jun 19, 2004·Hematology·Y Al-TonbaryR El-Shawaf
Nov 15, 2015·Nephrology·Aravind Selvin Kumar RamanathanBalakrishnan Karuppiah
Jul 18, 2018·Journal of the American Society of Nephrology : JASN·Xiaoyuan JiaUNKNOWN Research Consortium on Genetics of Childhood Idiopathic Nephrotic Syndrome in Japan
Aug 7, 2001·Scandinavian Journal of Urology and Nephrology·A Al-EisaB S Srivastva

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