PMID: 9659531Jul 11, 1998Paper

HLA-DQB1 and HLA-DPB1 genotypes in familial sarcoidosis

Respiratory Medicine
M SchürmannE Schwinger

Abstract

Numerous reports on the familial occurrence of sarcoidosis, on regionally different prevalences and on its associations with genetic polymorphisms point to the existence of predisposing genes. We have started to establish a collection of DNA from families with two or more sarcoidosis patients for the purpose of genetic linkage and association studies. In this report we present HLA class II genotypes of affected first-degree relatives from 17 families, including eight instances of affected parent and offspring, six sib pairs, and three sib triplets. Genotyping for HLA-DQB1 revealed an over-representation of DQB1*0603 and DQB1*0604 among alleles shared by affected first degree relatives. The same was found for HLA-DPB1*0201 (Glu69 positive). However, none of the sib triplets had any of these alleles in common.

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Citations

Mar 8, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Karoline I GaedeJoachim Müller-Quernheim
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·M SchürmannE Schwinger
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Michael C IannuzziBenjamin A Rybicki
Jan 30, 2003·American Journal of Respiratory and Critical Care Medicine·Benjamin A RybickiMichael C Iannuzzi
Jul 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Michael C IannuzziBenjamin A Rybicki
Oct 3, 2002·American Journal of Respiratory Cell and Molecular Biology·Hiroe SatoRoland M Du Bois
Jan 5, 2007·Proceedings of the American Thoracic Society·Michael C Iannuzzi, Benjamin A Rybicki
May 15, 2009·The American Journal of the Medical Sciences·James C BartonRonald T Acton
Jun 26, 2007·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Reury-Perng PerngYu-Mei Chung
Jun 10, 2008·Clinics in Chest Medicine·Joachim Müller-QuernheimStefan Schreiber
Jun 9, 2015·American Journal of Respiratory and Critical Care Medicine·Annegret FischerUNKNOWN GenPhenReSa Consortium
Jan 25, 2002·Respiratory Research·Panagiotis PantelidisRoland M du Bois
Dec 5, 2016·Orphanet Journal of Rare Diseases·Yves PachecoUNKNOWN GSF group

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