HLA-DQB1-defined genetic susceptibility, beta cell autoimmunity, and metabolic characteristics in familial and nonfamilial insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group

The Journal of Clinical Investigation
R VeijolaM Knip

Abstract

Familial aggregation of insulin-dependent diabetes mellitus (IDDM) is a common phenomenon, but the reasons behind it are poorly understood. To investigate whether there is heterogeneity between familial and nonfamilial forms of IDDM we compared genetic, immunological, and clinical characteristics of diabetic children with and without an affected first-degree relative in a population-based series of Finnish children with IDDM. The frequencies of HLA-DQB1 genotypes known to be associated with high (DQB1*0302/0201) or moderate (*0302/x) IDDM risk in the Finnish population were increased, while the proportions of DQB1 genotypes associated with low or decreased risk for IDDM were reduced in the 121 familial cases as compared with the 574 nonfamilial cases (32.7 vs. 21.3%, 41.3 vs. 35.9%, 18.3 vs. 31.4%, and 7.7 vs. 11.4%, respectively; P = 0.002). The frequencies and serum concentrations of islet cell antibodies, insulin autoantibodies, and antibodies to the 65-kD isoform of glutamic acid decarboxylase were similar at diagnosis in the familial and nonfamilial cases. The 31 first-affected cases in the multiple case families were younger at diagnosis than the nonfamilial cases (6.9 vs. 8.5 yr; P < 0.05). The 90 second-affected familia...Continue Reading

References

Jul 1, 1978·Annals of Human Genetics·B Degnbol, A Green
Dec 1, 1992·The Journal of Clinical Investigation·S Caillat-ZucmanJ F Bach
Dec 1, 1991·Diabetes Research and Clinical Practice·L A O'LearyA L Drash
Apr 6, 1989·The New England Journal of Medicine·J KarjalainenM Knip
Apr 16, 1988·Lancet·A C TarnE A Gale
Jul 19, 1984·The New England Journal of Medicine·J H WarramC R Kahn
Dec 1, 1994·International Journal of Epidemiology·G Dahlquist, L Mustonen

❮ Previous
Next ❯

Citations

Oct 8, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·Z PadaigaE Tuomilehto-Wolf
Mar 7, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·B AdojaanM Knip
Oct 16, 2012·European Journal of Endocrinology·Marco MariglianoClaudio Maffeis
Oct 4, 2012·Diabetes Care·Anna ParkkolaUNKNOWN Finnish Pediatric Diabetes Register
Sep 6, 2011·European Journal of Endocrinology·Anne HekkalaUNKNOWN Finnish Paediatric Diabetes Register
Jul 13, 2002·American Journal of Medical Genetics·Jorma IlonenChristos S Bartsocas
Sep 14, 2001·Best Practice & Research. Clinical Endocrinology & Metabolism·F K GorusUNKNOWN Belgian Diabetes Registry
May 29, 2010·Diabetes Care·Mikael KnipHans K Akerblom
Mar 5, 2002·Diabetes Care·Mikael Knip
Sep 14, 2007·Pediatric Diabetes·UNKNOWN TEDDY Study Group
Aug 16, 2005·Diabetes/metabolism Research and Reviews·Marika KukkoMikael Knip
Jun 27, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Shimon Efrat
Nov 30, 2006·Annals of the New York Academy of Sciences·William A HagopianBeena Akolkar
Feb 23, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Agostino MilluzzoLaura Sciacca

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.