HLA-DQB1 locus and gastric cancer in Helicobacter pylori infection

Journal of Gastroenterology and Hepatology
Yoshinori WatanabeM Kasuga

Abstract

It has been suggested that the incidence of digestive diseases associated with Helicobacter pylori is influenced by the strain diversity of H. pylori, factors involving the host or environment, and the duration of infection. The authors have previously reported that human leukocyte antigen (HLA)-DQB1*0401 plays an important role in the development of atrophic gastritis in H. pylori infected patients. The aim of the present study was to investigate the relationship between HLA-DQB1 genotype and cancer development. HLA-DQB1 genotyping was performed by the PCR-RFLP method on 122 H. pylori-infected non-ulcer dyspepsia (NUD) patients, 53 gastric cancer patients and 28 uninfected controls. To reliably estimate the grade of atrophic gastritis, histological evaluation was performed. The allele frequency of DQB1*0401 was significantly higher in intestinal type cancer patients compared with age- and sex-matched H. pylori-infected NUD patients. There was no significant difference in the mean atrophic scores of the biopsy samples from the lesser curvature of the mid-corpus between these groups. HLA-DQB1*0401 is a useful marker for determining susceptibility to intestinal type gastric cancer.

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Citations

Jun 30, 2009·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hidekazu SuzukiToshifumi Hibi
Jun 23, 2009·International Journal of Cancer. Journal International Du Cancer·Takashi AndoToshikazu Yoshikawa
Apr 19, 2018·Journal of Clinical Laboratory Analysis·Shen-Kang ZhouYong-Hua Zheng
Jun 28, 2007·International Journal of Cancer. Journal International Du Cancer·Eva Katalin TóthJudit Laki
Feb 2, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Roland M JonesPamela J Taylor
Apr 14, 2012·Journal of Clinical Gastroenterology·Young-Joo JinSoo Hyun Yang
Jan 5, 2007·World Journal of Gastroenterology : WJG·Roberto Herrera-GoepfertJulio Granados
Sep 15, 2020·World Journal of Gastroenterology : WJG·Suat SaribasBekir Kocazeybek
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Haijuan GuBin Wang

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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.