PMID: 9174152May 1, 1997Paper

HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

Tissue Antigens
J IlonenA Sochnevs

Abstract

The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ beta-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

References

Jan 1, 1992·Immunogenetics·C TautzX Baur
Jun 1, 1991·Journal of Neuroimmunology·M Victoria-GutierrezC López-Larrea
Mar 1, 1989·The Journal of Clinical Investigation·M J SheehyB S Nepom

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Citations

Apr 11, 2001·Human Immunology·R HermannA H Barnett
Jan 5, 2002·European Journal of Medicinal Chemistry·J PernakJ Cybulski
Nov 20, 1998·Tissue Antigens·A Foissac, A Cambon-Thomsen
Aug 25, 2012·World Journal of Diabetes·Youssef M MosaadFarha A El-Chennawi

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