HLA-DQB1*06 is a risk marker for chlamydia reinfection in African American women.

Genes and Immunity
Kristin M OlsonWilliam M Geisler

Abstract

Associations between human leukocyte antigen (HLA) variants and chlamydia-related outcomes have been inconsistent. We previously identified HLA-DQB1*06 as a risk marker for chlamydia reinfection in a cohort of predominately HIV-infected adolescents. As chlamydia reinfection can lead to reproductive complications, validation of this finding in HIV-seronegative women may help reveal the underlying biology. We performed HLA-DQB1 genotyping in HIV-seronegative, chlamydia-infected African American women who were evaluated for reinfection at 3- and 6-month visits after treatment. Of 185 evaluable women for whom HLA-DQB1 genotyping was performed, only HLA-DQB1*06 was associated with chlamydia reinfection (P = 0.009), with no evidence of a dose-response effect for this allele. African American women with HLA-DQB1*06 may warrant more frequent chlamydia screening. More comprehensive genotyping of HLA class II and neighboring genes is needed to establish whether HLA-DQB1*06 is a causal variant for chlamydia reinfection or a surrogate for other causal variants in the major histocompatibility complex.

References

Oct 23, 2004·The Journal of Infectious Diseases·William M GeislerRichard A Kaslow
Jul 21, 2009·Sexually Transmitted Diseases·Christina B HosenfeldHeidi M Bauer
May 28, 2010·The Journal of Infectious Diseases·Catherine L HaggertyRoberta B Ness
Dec 25, 2015·The New England Journal of Medicine·William M GeislerPeter R Kerndt

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Citations

Jan 4, 2020·The Journal of Infectious Diseases·Raymond M JohnsonGang Peng
Dec 22, 2020·American Journal of Obstetrics & Gynecology MFM·Jodie Dionne-OdomJeanne Marrazzo
Feb 7, 2021·Animals : an Open Access Journal From MDPI·Bonnie L Quigley, Peter Timms

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Methods Mentioned

BETA
gene knockout
genotyping
nucleic acid amplification
contraception
electrophoresis

Software Mentioned

SAS

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