PMID: 8605101Mar 1, 1996Paper

HLA-DR antigen expression in colorectal carcinomas: influence of expression by IFN-gamma in situ and its association with tumour progression

British Journal of Cancer
Kazuyuki MatsushitaK Isono

Abstract

The authors attempted to investigate the host's immune response against colorectal carcinoma through the expression of HLA-DR antigen on carcinoma cells (Ca) on normal epithelia immediately adjacent to carcinoma (AN) in relation to tumour progression. The expression of HLA-DR antigen on Ca and on normal epithelia, both on AN and those 5-10 cm removed from the carcinoma (RN), were examined immunohistochemically. mRNAs of cytokines, IFN-gamma and TNF-alpha, were detected by reverse transcription-polymerase chain reaction (RT-PCR) in both carcinoma and remote normal tissues. The expression of HLA-DR antigen on AN was significantly increased compared with RN. Patients with tumours showing HLA-DR staining both in Ca and AN were in less advanced Dukes' stages (Dukes' A or B) compared with those without the stain. Furthermore, the expression of HLA-DR antigen in normal mucosa coincided significantly with the existence of IFN-gamma mRNA. Detection in carcinoma tissues of IFN-gamma mRNA that leads to the induction of HLA-DR antigen on AN could be an indicator of a host's immune response to carcinoma. These in vivo observations might be clinically applicable to the prediction of patients' immune responsiveness to carcinomas.

Citations

Jun 17, 1999·International Journal of Cancer. Journal International Du Cancer·F PagèsW H Fridman
Aug 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Georg E SteinerMichael Marberger
Feb 26, 2004·Cancer·Subramanian KrishnakumarJyotirmay Biswas
Jan 7, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Motohiro NonakaToshisuke Kawasaki
Mar 5, 1998·Journal of the National Cancer Institute·E TartourW H Fridman
May 7, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·B SikorskaM Wagrowska-Danilewicz
Oct 17, 2003·Current Eye Research·Dhiraj AbhyankarSubramanian Krishnakumar
Oct 8, 2020·International Journal of Molecular Sciences·Francesco SabbatinoStefano Pepe
Feb 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elza C de BruinJan Paul Medema
Dec 12, 2020·Cancer Science·Sohei KobayashiKazuyuki Matsushita

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