PMID: 6977488Jan 1, 1981Paper

HLA-DR antigens induce proliferation and cytotoxicity of T cells against haptenated (TNP and FITC) self structures

Immunogenetics
R PalaciosP A Peterson

Abstract

Antisera directed against the heavy, the light, or reactive against the complex of both chains of HLA-DR antigens strongly inhibited proliferation of T cells induced by TNP- or FITC-labeled autologous cells when added at initiation of the cultures, but not 72 h later. T cells from cultures treated with the anti-DR sera were unresponsive to interleukin-2 (IL-2). Nonetheless, the anti-DR sera did not inhibit proliferation of T cells that had already acquired sensitivity to IL-2. The DR antibodies abrogated the synthesis of IL-2 induced by both TNP-and FITC-conjugated autologous cells. Treatment of TNP-and FITC-labeled autologous cell cultures with the four different types of anti-DR sera significantly inhibited the induction of cytotoxic T cells. However, DR antibodies added at the effector phase of cytotoxicity assays did not inhibit the cytotoxic activity. Effector T cells from cultures treated with the anti-DR sera were unresponsive to IL-2 and addition of IL-2 to these cultures did not restore the cytotoxic activity. In contrast, effector T cells from cultures performed in the absence of the anti-DR sera proliferated to Il-2 stimulation and addition of IL-2 to these cultures significantly increased the generation of killer ce...Continue Reading

References

Apr 1, 1978·Tissue Antigens·E Thorsby
Sep 8, 1977·Nature·W NewmanB R Bloom
Mar 25, 1977·Science·W E Paul, B Benacerraf
Aug 1, 1974·European Journal of Immunology·G M Shearer
Sep 1, 1981·Scandinavian Journal of Immunology·R Palacios
Jun 1, 1980·The Journal of Clinical Investigation·R PalaciosE Díaz-Jouanen
May 1, 1981·The Journal of Experimental Medicine·R Palacios, G Möller
Apr 30, 1981·Nature·R Palacios, G Möller

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