HLA-DR expression on arachnoid cells. A role in the fibrotic inflammation surrounding nerve roots in spondylotic cervical myelopathy

Spine
E Frank

Abstract

Human arachnoid cells were examined immunohistochemically for expression of HLA-DR or Fc receptors. To assess the ability of arachnoid cells to express HLA-DR and act as antigen presenting cells. An intradural inflammatory reaction surrounds the cervical nerve roots and radicular vessels in patients with spondylotic cervical myeloradiculopathy. Active arachnoid proliferation and fibrosis in this reaction suggest these cells are actively involved in this inflammatory process. An inflammatory response is initiated by an antigen presenting cell. Evidence suggests that arachnoid cells may be antigen presenting cells, like macrophages, because they can phagocytize foreign tissue and have immunoglobulin G and complement receptors. Spinal arachnoid obtained from patients undergoing spinal surgery for intramedullary processes was grown in culture. The arachnoid cells were characterized and examined immunohistochemically for the expression of HLA-DR and Fc receptors. HLA-DR was expressed in vivo and in vitro by arachnoid cells. The macrophage Fc receptor was not expressed in vivo nor in vitro by arachnoid cells. Finding in vivo and in vitro HLA-DR expression on arachnoid cells adds further support to the concept that arachnoid cells hav...Continue Reading

Citations

Dec 7, 2006·Pain Practice : the Official Journal of World Institute of Pain·Phillip S SizerOmer Matthijs
May 24, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Shunji MatsunagaYoshiaki Toyama
Mar 13, 2017·Experimental Brain Research·Eric A HansenCornelius H Lam
Jan 28, 2005·Journal of Neuro-oncology·Arie PerryGuido Reifenberger

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