HLA-DR expression on myeloid cells is a potential prognostic factor in patients with high-risk neuroblastoma

Oncoimmunology
Madhu GowdaMasoud H Manjili

Abstract

The adaptive immune system has been reported to play a dual role in many cancers, on one hand inhibiting tumor growth and, on the other hand, promoting disease progression, escape from cancer immunosurveillance and relapse. We have previously reported that the suppression of the adaptive immune response associated with high levels of myeloid-derived suppressor cells (MDSC) was evident in patients with low-risk neuroblastoma. Here, we report the results of a pilot study demonstrating that the amounts of HLA-DR-positive or negative myeloid cells in the peripheral blood might predict disease outcome among individuals affected by high-risk neuroblastoma.

References

Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K K MatthayJ N Lukens
May 30, 2003·The Oncologist·Joanna L WeinsteinSusan L Cohn
Aug 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W B LondonS L Cohn
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven A RosenbergSeth M Steinberg
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Hui PengJialin Zheng
Jun 8, 2011·International Journal of Biological Sciences·Brian F Zamarron, WanJun Chen
Jun 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maciej KmieciakMasoud H Manjili
Oct 8, 2011·Journal of Translational Medicine·Madhu GowdaMasoud H Manjili
Jun 22, 2012·Oncoimmunology·Masoud H Manjili, Kyle K Payne
Apr 1, 1980·Cancer·Audrey E Evans

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Citations

Feb 28, 2020·Cancers·Celina L SzantoStefan Nierkens
Jun 17, 2020·The Journal of Clinical Investigation·Rachael L TerryPaul J Neeson
Jan 4, 2019·Journal of Cancer Research and Clinical Oncology·Ying WangPinan Liu

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