PMID: 9641505Jun 26, 1998Paper

HLA-DR gene frequencies in a Zaïrean population with particular reference to rheumatic diseases

Clinical Rheumatology
K MbayoZ Lurhuma

Abstract

Epidemiological studies have shown that rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus are uncommon in black Africans, and in this population the prevalence and the clinical features of these rheumatic diseases are variable. Environmental and genetic factors have been pointed out to explain this variability. In the present study, HLA-DR genes have been determined in a Zaïrean population in order to compare our results with those found elsewhere in other black populations of the same Bantu origin. Our results show that the frequency of HLA-DR1 is higher than in Nigerians, Zimbabweans and Xhosas, the decrease in Xhosas being statistically significant (p < 0.006). The HLA-DR3 frequency is higher in Zaïreans than in Nigerians but not significantly, while it is lower than in Xhosas (p < 0.003) and in Zimbabweans (not significant). The HLA-DR4 frequency is higher in Zaïreans than in Nigerians but it is lower than in Xhosas and Zimbabweans; the differences are not statistically significant. The HLA-DR8 frequency is lower in Zaïreans than in Nigerians while it is higher than in Xhosas (p < 0.002) and in Zimbabweans (not significant). These data suggest that genetic factors partly explain the clinical a...Continue Reading

References

Apr 1, 1975·Annals of the Rheumatic Diseases·L SolomonH A Valkenburg
Apr 1, 1975·Annals of the Rheumatic Diseases·P BeightonH A Valkenburg
Sep 1, 1990·Tissue Antigens·E D du ToitM Oudshoorn
Sep 1, 1990·Tissue Antigens·R W MartellE D du Toit
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B P WordsworthJ I Bell
Jan 1, 1989·Annals of the Rheumatic Diseases·G M Mody, O L Meyers
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Mar 1, 1985·Tissue Antigens·R C OkoyeH Festenstein
Jan 1, 1973·International Archives of Allergy and Applied Immunology·G FernandesR A Good
Sep 1, 1969·Annals of the Rheumatic Diseases·B M Greenwood
Jan 1, 1970·Transactions of the Royal Society of Tropical Medicine and Hygiene·B M Greenwood, A Voller
Sep 1, 1966·Annals of the Rheumatic Diseases·J S LawrenceH Robinson
Oct 1, 1983·Postgraduate Medical Journal·P A Bacon
Feb 1, 1984·Annals of the Rheumatic Diseases·J D MoolenburghM G Erasmus
Jan 1, 1980·Physiological Reviews·R L Gross, P M Newberne
Feb 1, 1995·Baillière's Clinical Rheumatology·I E Haffejee
Feb 1, 1995·Baillière's Clinical Rheumatology·A O Adebajo
Feb 1, 1995·Baillière's Clinical Rheumatology·G M Mody
Feb 1, 1995·Baillière's Clinical Rheumatology·I E Haffejee
Sep 1, 1994·Tissue Antigens·L HalleC Kaplan
Nov 1, 1995·Baillière's Clinical Rheumatology·L G ClelandM J James
Oct 1, 1955·Annals of Human Genetics·R CEPPELLINIC A SMITH
Dec 5, 1964·Nature·P I TERASAKI, J D MCCLELLAND

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Citations

Jun 1, 2005·The Medical Clinics of North America·Gail S KerrE Nigel Harris
Aug 21, 2013·Arthritis Research & Therapy·J J MalembaP Verschueren
Dec 4, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M Gibert, A Sanchez-Mazas
Sep 17, 2013·Pediatric Rheumatology Online Journal·James ChipetaRichard Bucala

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