Jan 1, 1989

HLA-DR molecules on all cells are electrophoretically unique

Leukemia Research
J M PesandoM A Stucki


Previous SDS-PAGE studies of autologous clonal ALL and normal B cell lines indicated that HLA-DR molecules on leukemic cells have an extra beta chain band. We now show that these results are not an artifact of cell lines, EBV transformation, or cell growth in culture. Leukemic cells from four ALL patients were surface labeled with 125I and their HLA-DR molecules compared with those on autologous normal peripheral blood B cells. The electrophoretic patterns of HLA-DR molecules on these in vivo cell populations are identical to those on the corresponding cell lines. Moreover, EBV-transformation does not alter the electrophoretic appearance of HLA-DR molecules on normal tonsil B cells. Cell lines can now be used to study the chemical basis for these electrophoretic differences.

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Mentioned in this Paper

Leukemia, Lymphocytic, Acute, L2
Peripheral Blood
CD19 Antigens
Benign Neoplasm of Tonsil
Cell Growth
Tonsillar Tissue
HLA-DR Antigens

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