HLA-DR2 and narcolepsy

Archives of Neurology
R E KramerG A Teresi


Tissue typing was performed on 14 narcoleptics as defined by both strict sleep laboratory and clinical criteria. Six of these patients were blacks from North America, a race underrepresented in previous studies. All patients were HLA-DR2-antigen positive and had the same HLA-DR2 subtype. Clinical severity of disease was not correlated with HLA-DR2 heterozygosity or (putative) homozygosity. This study confirms that the extremely high association between HLA-DR2 and narcolepsy holds across comparisons of the three races studied to date when both clinical and sleep laboratory data are used. The presence or absence of HLA-DR2 in patients presenting with hypersomnolence may help support or exclude, respectively, a diagnosis of idiopathic narcolepsy.


Dec 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·G C DeLucaG C Ebers
Jun 1, 1991·Acta Neurologica Scandinavica·C HublinS Koskimies
May 23, 1992·Lancet·M DahlitzJ D Parkes
Aug 1, 1990·Annals of Neurology·L H Sigal
Nov 1, 1989·Journal of Neurosurgery·J L GoodP S Fishman
Mar 1, 1991·Acta Neuropsychiatrica·W M Verhoeven
Aug 1, 1990·Annals of Neurology·F VisscherL M Smit
Aug 11, 2000·Paediatric Drugs·C Guilleminault, R Pelayo

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