PMID: 8450297Mar 1, 1993Paper

HLA-DR3, DQ2 homozygosity in two patients with insulin-dependent diabetes mellitus superimposed with ulcerative colitis and primary sclerosing cholangitis

Journal of Internal Medicine
S A IvarssonR Wassmuth

Abstract

Two unrelated young males with the unusual simultaneous presence of insulin-dependent diabetes mellitus, ulcerative colitis and primary sclerosing cholangitis are reported. Both patients manifested homozygosity for the DR3-DQw2 (DQB*0201) HLA genotypes. We believe that homozygosity for this genotype may predispose for this type of multi-organ autoimmune disease.

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Citations

Nov 25, 2004·Clinics in Liver Disease·A Bergquist, U Broomé
Jan 1, 1997·Inflammatory Bowel Diseases·E V LoftusN F Larusso

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