HLA-DR3 in dermatitis herpetiformis

The British Journal of Dermatology
H PehambergerW R Mayr

Abstract

Twenty-one patients with dermatitis herpetiformis were typed for HLA-ABC and -DR determinants. The incidence of HLA-AI, -B8 and -DR3 antigens was found to be significantly higher (P: = 10(-3), less than 10(-6) and less than 10(-6), respectively) among patients with dermatitis herpetiformis than among the normal population. HLA-DR3 was found in 85.7% of patients, HLA-B8 in 66.7% and HLA-AI in 61.9% only. These results indicate that HLA-DR3 is the antigen primarily associated in dermatitis herpetiformis and the latter antigens (HLA-AI and -B8) are present in increased incidence, probably due to the known linkage disequilibrium of these antigens with HLA-DR3.

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Citations

Mar 1, 1986·The American Journal of Medicine·J D Heironimus, E L Perry
Jul 1, 1997·Tissue Antigens·A BalasD García-Novo
Aug 1, 1996·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M A HallP J Ciclitira
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