PMID: 8601742Feb 1, 1996Paper

HLA-DR4 may determine expression of actinic prurigo in British patients

The Journal of Investigative Dermatology
Menagé H duPJ L Hawk

Abstract

Human leukocyte antigen (HLA) associations have been reported in Amerindian patients with actinic prurigo. To determine if similar associations are present in the British Caucasoid population with actinic prurigo, 26 patients underwent serological typing for HLC Class I and II antigens. DNA analysis by both sequence-specific priming and group-specific amplification with single-stranded oligonucleotide probe hybridization was used to confirm the DR and DQ typing and to perform DR4 subtyping. All patients were DR4 positive, and 25 of 26 patients were DQ7 positive. DR4 subtyping revealed 12 of 20 patients tested to be DRB1*0407. A nonsignificant association was also found with HLA B55 that is in linkage disequilibrium with DRB1*0407. No HLA associations were found in 25 British Caucasoid patients with polymorphic light eruption. DRB1*0407 is rare in European Caucasoids without actinic prurigo, and HLA-DR4 may have an important role in determining expression of this disease.

Citations

Feb 12, 1998·The British Journal of Dermatology·R S Dawe, J Ferguson
Aug 28, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·A J StratigosA D Katsambas
Aug 16, 2003·Dermatologic Therapy·María-Teresa Hojyo-TomokaLuciano Domínguez-Soto
May 16, 2002·International Journal of Dermatology·Angela UmañaLuisa Porras
Feb 13, 2001·The British Journal of Dermatology·M L BatardP Thomas
Aug 8, 2001·The Australasian Journal of Dermatology·J C NgC S Baker
Dec 1, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·E SmithA V Anstey
Aug 24, 2013·International Journal of Dermatology·Diana Sugey Vera IzaguirreMaria Elisa Vega Memije
Sep 22, 2019·Photodermatology, Photoimmunology & Photomedicine·Martha Cecilia Valbuena, Mariam Rolon Cadena
Nov 28, 2001·Clinical and Experimental Dermatology·S A GrabczynskaR W Vaughan
Jun 3, 1999·The British Journal of Dermatology·B F O'DonnellM W Greaves
Apr 12, 2006·Photodermatology, Photoimmunology & Photomedicine·Alfonso SuárezLuisa de Porras Quintana
May 8, 1999·The British Journal of Dermatology·S A GrabczynskaJ L Hawk
Jan 21, 2016·Photochemistry and Photobiology·Qiping ChenWei-Sheng Chong
Feb 6, 2016·The British Journal of Dermatology·L MacfarlaneS Ibbotson
Jul 1, 2018·American Journal of Clinical Dermatology·Amanda F NahhasHenry W Lim
Jun 1, 1997·Photodermatology, Photoimmunology & Photomedicine·S A Grabczynska, J L Hawk
Jul 21, 2005·The British Journal of Dermatology·C M PerrettJ M McGregor
Jun 1, 1997·Photodermatology, Photoimmunology & Photomedicine·P R Lane
Apr 24, 1999·The British Journal of Dermatology·R M AzurdiaA Edwards
Oct 2, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·F Kiss, A V Anstey
Dec 22, 1999·Seminars in Cutaneous Medicine and Surgery·J Ferguson, S Ibbotson
Feb 29, 2000·The Journal of Dermatology·R Akaraphanth, P Gritiyarangsan
Oct 18, 2015·International Journal of Dermatology·Maria S Kryatova, Ginette A Okoye
Oct 23, 2021·Dermatologic Therapy·Miroslava KadurinaGeorgeta Bocheva

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