PMID: 9442803Jan 27, 1998Paper

HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
H ReijonenJ Ilonen

Abstract

We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM.

Citations

Jul 21, 2010·Current Diabetes Reports·Jorma Ilonen, Robert Hermann
Sep 21, 2000·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J IlonenH K Akerblom
Mar 16, 2004·Pediatric Diabetes·O CinekK S Ronningen
Feb 12, 2017·HLA : Immune Response Genetics·M-L MikkUNKNOWN Finnish Paediatric Diabetes Register
Jun 28, 2001·Clinical and Diagnostic Laboratory Immunology·V KumarJ Wortsman
Jul 30, 2002·Tissue Antigens·Z M VelickovicJ M Carter
Aug 17, 2012·Current Diabetes Reports·Johanna Lempainen, Jorma Ilonen
Jul 13, 2002·American Journal of Medical Genetics·Jorma IlonenChristos S Bartsocas
Mar 22, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·K A Al-HusseinM G Tilanus

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