HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.

Proceedings of the National Academy of Sciences of the United States of America
B P WordsworthJ I Bell

Abstract

Susceptibility to rheumatoid arthritis (RA) may be due to the presence of shared functional epitopes common to the HLA-DR beta chains of several RA-associated haplotypes. We have obtained direct evidence for this hypothesis by using the polymerase chain reaction and sequencing the DRB1 and DQB1 genes from RA patients. A highly conserved epitope present on DR beta chains of DR4 and DR1 haplotypes was found in 83% of 149 patients with classical or definite RA but was found in only 46% of 100 control individuals (P less than 0.0001). Two Dw subtypes of DR4 (Dw4 and Dw14) were associated with disease susceptibility but two other subtypes (Dw10 and Dw13) were not. Sequence differences between these subtypes implicate those residues around the putative antigen binding site of the DR beta molecule in the pathogenesis of RA. These data provide a basis for understanding host susceptibility to RA at a molecular level.

References

Jun 1, 1977·Arthritis and Rheumatism·A J McMichaelR O Payne
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G T HornH A Erlich
Dec 9, 1985·Nucleic Acids Research·M M WayeG Winter
Dec 1, 1988·Baillière's Clinical Rheumatology·D M Grennan, P A Sanders
Dec 1, 1987·Baillière's Clinical Rheumatology·J R Kirwan, A J Silman
May 20, 1988·Science·J A ToddL Steinman
Jan 1, 1988·British Journal of Rheumatology·Z Jajić, I Jajić
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P K GregersenJ Schwenzer
Aug 1, 1986·Annals of the Rheumatic Diseases·D JaraquemadaR N Maini
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J I BellH O McDevitt
Nov 14, 1981·British Medical Journal·J C WoodrowG Zaphiropoulos
Aug 1, 1982·Annals of the Rheumatic Diseases·B SchiffE Gazit

❮ Previous
Next ❯

Citations

Jul 14, 1999·American Journal of Medical Genetics·S GibsonM Gill
Jul 22, 1998·Genetic Epidemiology·E GéninF Clerget-Darpoux
Jul 1, 1991·Arthritis and Rheumatism·J Stedeford, B P Wordsworth
May 1, 1993·Arthritis and Rheumatism·B LangI Melchers
Aug 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C M Milner, R D Campbell
Dec 4, 1998·Springer Seminars in Immunopathology·A P Cope, G Sønderstrup
Jan 1, 1995·Immunologic Research·L I Sakkas, C D Platsoucas
Jan 1, 1994·Immunologic Research·L I SakkasC D Platsoucas
Jan 1, 1993·Immunologic Research·F DedeogluJ J Marchalonis
Nov 15, 2002·International Journal of Hematology·Richard K BurtAlberto M Marmont
May 25, 2012·Rheumatology International·Devaraj Jatteppa ParasannanavarKanjaksha Ghosh
Feb 14, 2008·Clinical Reviews in Allergy & Immunology·Rene Donizeti OliveiraPaulo Louzada-Junior
Jul 31, 1993·Lancet·K PileP Wordsworth
Jun 1, 1991·Journal of Neuroimmunology·M Victoria-GutierrezC López-Larrea
Dec 1, 1991·Human Immunology·X Gao, S W Serjeantson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.