HLA-DR7 in association with chlorpromazine-induced lupus anticoagulant (LA)

Journal of Autoimmunity
Gilberto Vargas-AlarcónJ Granados

Abstract

The presence of anti-phospholipid antibodies (aPL) has been associated with the major histocompatibility complex (MHC) genes. These autoantibodies occur in individuals with infections such as that produced by the human immunodeficiency virus 1 (HIV-1) or with syphilis, but they can also occur in drug-induced lupus-like syndromes. In the present study, we analysed the presence of aPL (detected as lupus anti-coagulant) and its relationship with the MHC markers in 93 Caucasian psychiatric patients chronically treated with chlorpromazine. Forty-one out of 93 patients were positive for LA, and the HLA-DR7 antigen was significantly increased in LA-positive patients as compared to normal controls or LA-negative patients (PC = 0.024, RR = 2.12 and P = 0.05, RR = 1.57, respectively). Likewise, we noted a significantly increased frequency of HLA-B44 in LA-positive patients as compared to normal controls (PC = 0.024, RR = 2.12), but not when compared to aPL-negative patients. No significant differences were found among any other class I, II or III MHC antigens. Haplotype analysis showed that DR7 was mostly part of the HLA-B44-DR7-FC31 and B7-DR7-SC31 haplotypes. These results suggest that the HLA-DR7 antigen might be playing a role in the...Continue Reading

Citations

Feb 22, 2008·Psychiatry and Clinical Neurosciences·Radovan MalýKaterina Konupcíková
Dec 13, 2006·Lupus·Y LevyY Shoenfeld
Jan 5, 2014·British Journal of Haematology·Aurélien DellucKarine Lacut
Dec 24, 2004·Diabetes Care·Janet SilversteinUNKNOWN American Diabetes Association
Jan 3, 2001·Clinics in Dermatology·S R Porter, C Scully
Dec 1, 2009·The Psychiatric Clinics of North America·Sun Young YumMichael Y Hwang

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