HLA-DRB alleles are differentially expressed by tumor cells in breast carcinoma

International Journal of Cancer. Journal International Du Cancer
Sharon A OldfordSheila Drover

Abstract

The biologic and prognostic significance of HLA-DR expression and T-cell infiltration in breast carcinoma are presently controversial. To test the hypothesis that these factors are influenced by particular HLA-DRB alleles, 52 breast tumor samples, composed of 26 DRB1*04 and 26 non-DRB1*04 tumors, were assessed using immunohistochemistry for expression of DR and its associated invariant chain (Ii) and for infiltrating CD3+ T cells. While DR expression by tumor cells was significantly associated with T-cell infiltration, DRB1*04 tumors were more frequently DR+ Ii+ and contained smaller CD3+ infiltrates than non-DRB1*04 tumors. This difference was largely attributable to DRB1*07 tumors, which were typically DR- Ii-, although they contained similar numbers of T cells to DR+ Ii+ tumors. Further analysis of DR+ tumors using allotype discriminating antibodies revealed that DRB1*04 alleles were always expressed, while non-DRB1*04 alleles were inconsistently expressed. The results of this study provide the first reported evidence that DRB alleles influence DR expression and T-cell infiltration in breast carcinoma and suggest that multiple factors contribute to DR expression. Ongoing studies aimed at elucidating the molecular and immunol...Continue Reading

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Citations

Jan 23, 2016·Biomaterials·C G Da SilvaLuis J Cruz
Jul 26, 2006·Experimental Hematology·Carol SheridanHarikrishna Nakshatri
Nov 13, 2014·International Journal of Cancer. Journal International Du Cancer·Adriane GardyanStefan B Eichmüller
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Aug 17, 2019·Nature Reviews. Immunology·Robert LanzaAndras Nagy
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Nov 23, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Margaret L AxelrodJustin M Balko
Apr 17, 2021·Cancer Metastasis Reviews·Ignacio AlgarraAngel M Garcia-Lora

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