HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

Journal of Clinical and Experimental Hepatology
Navchetan KaurYogesh K Chawla

Abstract

Autoimmune hepatitis is a polygenic disorder of unknown etiology, where genetic factors affect the occurrence and clinical phenotype of the disease. It has been reported as a rare disease entity in the Indian subcontinent. This study was undertaken to investigate the association of HLA alleles with autoimmune hepatitis type 1 and type 2 in north Indian population and to analyze if distinct human leukocyte antigen (HLA) alleles help in characterization of the subtypes of autoimmune hepatitis. Sixty-eight patients with autoimmune hepatitis and 128 healthy controls were recruited in the study. Out of 68 patients, 55 were diagnosed with autoimmune hepatitis type 1 and 13 with autoimmune hepatitis type 2. The patients and the controls were typed for HLA class II alleles by PCR-SSP method. HLA DRB1*04 and DRB1*08 were found to be significantly associated with autoimmune hepatitis type 1 in north Indian population. It was also observed that DRB1*04, DRB1*13 were significantly associated with pediatric autoimmune hepatitis type 1 and DRB1*08 was significantly associated with adult autoimmune hepatitis type 1. DRB1*14 was significantly associated with autoimmune hepatitis type 2. The study indicates that autoimmune hepatitis in north In...Continue Reading

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Citations

Jan 19, 2016·Human Immunology·Rasoul BaharlouNader Tajik
Jun 8, 2018·HLA : Immune Response Genetics·C M GambinoG Candore
Mar 27, 2018·Journal of Clinical and Translational Hepatology·Qi-Xia WangXiong Ma
May 18, 2019·Journal of Digestive Diseases·Rui Ling ChenXiong Ma
May 31, 2018·Biochemical Genetics·Marwa ChaoualiRadhia Kochkar

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