HLA-DRB1 alleles of susceptibility and protection in Iranians with autoimmune hepatitis

Human Immunology
Rasoul BaharlouNader Tajik

Abstract

Autoimmune hepatitis (AIH) is an uncommon autoimmune liver disease of unknown etiology. The aim of this study was to determine the frequency of HLA-DRB1 alleles in Iranian patients with AIH and investigate the association between HLA alleles and the different types of the disease. Fifty-four AIH patients and 100 age- and sex-matched healthy controls were subjected to low resolution HLA-DRB typing performed by polymerase chain reaction-sequence-specific primers (PCR-SSP) technique. The results revealed higher frequencies of HLA-DRB1(∗)03, and DRB1(∗)13 alleles in patients with AIH compared to controls. However, DRB1(∗)11 was less frequent in AIH patients. In type I AIH patients HLA-DRB1(∗)03, HLA-DRB1(∗)04, HLA-DRB1(∗)08, and HLA-DRB1(∗)13 were the most frequent alleles. While in type II, the most frequent alleles were HLA-DRB1(∗)07 and HLA-DRB1(∗)13. The seronegative patients showed more frequency of HLA-DRB1(∗)03 and HLA-DRB3. In contrary, the frequency of HLA-DRB1(∗)11, HLA-DRB1(∗)15 and HLA-DRB5 in type 1 was less than healthy individuals. These findings indicate the role of HLA-DRB haplotypes in AIH susceptibility and protection, in the Iranian population.

References

Apr 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P T DonaldsonR Williams
Apr 4, 1996·The New England Journal of Medicine·E L Krawitt
Sep 5, 1996·The New England Journal of Medicine·J D Rich
Jun 1, 1997·Gastroenterology·M D StrettellR Williams
Jul 22, 1998·Journal of Hepatology·M N Vázquez-GarcíaC Gorodezky
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PandoL Fainboim
Oct 5, 2002·Clinics in Liver Disease·Kirsten Muri Boberg
Mar 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Albert J Czaja
Mar 7, 2009·World Journal of Gastroenterology : WJG·Kathie BélandFernando Alvarez
Sep 22, 2009·Journal of Autoimmunity·Maria Serena LonghiDiego Vergani
Jun 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael P MannsUNKNOWN American Association for the Study of Liver Diseases
Oct 12, 2010·Autoimmunity Reviews·Lea Campos OliveiraAnna Carla Goldberg
Nov 12, 2010·Italian Journal of Pediatrics·Amel A M ElfaramawyHeba M Abdel Aziz
May 4, 2011·Nature Reviews. Gastroenterology & Hepatology·Giorgina Mieli-Vergani, Diego Vergani
Feb 16, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kaname YoshizawaMorikazu Onji
Dec 12, 2012·Journal of Autoimmunity·Rodrigo LiberalDiego Vergani
Dec 21, 2013·Hepatitis Monthly·Nasir HassanMirza Naqi Zafar
Apr 29, 2014·Gastroenterology·Ynto S de BoerUNKNOWN Study of Health in Pomerania
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Navchetan KaurYogesh K Chawla

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