HLA-DRB1: genetic susceptibility and disability progression in a Spanish multiple sclerosis population.

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
L Romero-PinelT Arbizu

Abstract

The association of HLA-DRB1*15 with susceptibility to multiple sclerosis (MS) has been consistently reported although its effect on the clinical phenotype is still controversial. The objectives of this study are to investigate the influence of the HLA-DRB1 alleles on the genetic susceptibility to MS and to study their impact on disability progression in a Spanish population. HLA-DRB1 typing was performed by PCR-SSP in 380 patients with sporadic MS and 1088 unrelated healthy controls. Allelic frequencies were compared between groups. We studied the correlation between the different alleles and the progression of MS. The HLA-DRB1*15 allele in patients with MS had a statistically significant higher frequency when compared with controls (18.9% in patients vs. 10.1% in controls, Odds ratio (OR)=2.07, 95% CI=1.64-2.60, P<0.001). In the univariate analysis, the DRB1*01 and DRB1*04 alleles were associated with a worse prognosis when considering the time to reach an EDSS of 6, whereas the DRB1*03 was correlated with a better outcome. In the multivariate analysis, the alleles*01 and *04 were demonstrated to be independent factors to have a worse prognosis. HLA-DRB1*15 is associated with MS when comparing patients with unrelated healthy c...Continue Reading

References

Aug 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·C ConfavreuxA J Thompson
May 1, 1994·Journal of Neurology·B RunmarkerO Andersen
Aug 1, 1996·Nature Genetics·G C EbersN Risch
Jul 30, 1999·Journal of the Neurological Sciences·G V McDonnellD Middleton
Aug 12, 2000·Annals of Neurology·T MastermanJ Hillert
Jan 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·A E HensiekD A S Compston
Feb 9, 2002·Brain : a Journal of Neurology·L F BarcellosUNKNOWN Multiple Sclerosis Genetics Group
Jan 30, 2004·Lancet Neurology·David A DymentA Dessa Sadovnick
Apr 15, 2004·Journal of Neuroimmunology·Clara BalleriniSandra D'Alfonso
Jul 29, 2004·European Journal of Human Genetics : EJHG·Carlos FloresPeter A Underhill
Jan 26, 2005·Neurology·D BrassatG Savettieri
Jun 3, 2005·Human Molecular Genetics·David A DymentGeorge C Ebers
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Aug 15, 2006·Human Molecular Genetics·Lisa F BarcellosJorge R Oksenberg
Mar 3, 2007·American Journal of Epidemiology·Hollie SchmidtAllison Ashley-Koch
Apr 7, 2007·Journal of the Neurological Sciences·Ana Martins SilvaBerta Martins
Jul 31, 2007·The New England Journal of Medicine·UNKNOWN International Multiple Sclerosis Genetics ConsortiumStephen L Hauser
Jul 31, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C SmestadH F Harbo
Sep 12, 2007·PLoS Genetics·Sreeram V RamagopalanGeorge C Ebers
Dec 7, 2007·Neurology·G DeanD A S Compston
Dec 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·G C DeLucaG C Ebers
Feb 16, 2008·Lancet Neurology·George C Ebers
Feb 26, 2008·Lancet·Sreeram V Ramagopalan, George C Ebers
Apr 11, 2008·Genes and Immunity·I A HoppenbrouwersR Q Hintzen
May 21, 2008·Brain : a Journal of Neurology·Stephen Sawcer
Jul 11, 2008·Genes and Immunity·I Cournu-RebeixB Fontaine
Jul 18, 2008·Journal of Neuroimmunology·Sreeram V RamagopalanGeorge C Ebers
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michael J ChaoGeorge C Ebers
Oct 22, 2008·Neurology·S V RamagopalanG C Ebers
Oct 28, 2008·Trends in Neurosciences·Sreeram V RamagopalanGeorge C Ebers
Nov 11, 2008·Nature Genetics·Yurii S AulchenkoRogier Q Hintzen
Nov 18, 2008·Human Molecular Genetics·Sergio E BaranziniJorge R Oksenberg
Feb 11, 2009·Archives of Neurology·Bruce A C CreeJorge R Oksenberg
Feb 11, 2009·Neurology·Sreeram V Ramagopalan, George C Ebers
Apr 15, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L PatruccoE Cristiano
Apr 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Matthew R LincolnGeorge C Ebers
Apr 24, 2009·Current Opinion in Neurology·Sreeram V RamagopalanGeorge C Ebers

❮ Previous
Next ❯

Citations

Mar 23, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L Romero-PinelT Arbizu
Sep 14, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H Schapira, M Hillbom
Jul 30, 2014·Journal of the Neurological Sciences·Roya AbolfazliAbbas Shakoori
Jan 5, 2011·Autoimmune Diseases·Giulio DisantoJulia M Morahan
Jun 26, 2012·Immunological Reviews·Pierre-Antoine GourraudSergio E Baranzini
Jul 6, 2016·Human Immunology·Iñigo RomònStéphane Buhler
Nov 1, 2016·Acta neurologica Belgica·Andreas P LysandropoulosMichel Toungouz
Jul 17, 2013·Therapeutic Advances in Neurological Disorders·Hanne F HarboMar Tintoré
Nov 14, 2017·HLA : Immune Response Genetics·M Al JumahA H Hajeer
Dec 28, 2019·The Journal of International Medical Research·O Al Wutayd

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.