HLA-DRB1*03 and DRB1*04 are associated with atrophic gastritis in an Italian population

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Edith LahnerBruno Annibale

Abstract

Atrophic gastritis (AG) is often considered an autoimmune disorder and is associated with other autoimmune diseases. HLA-DRB1 alleles are often associated with autoimmune diseases, however HLA-DRB1 genotyping data in AG patients are lacking. The objective of the study was to evaluate the prevalence of HLA-DRB1 in AG patients. The occurrence of HLA-DRB1 alleles was assessed in 89 Italian AG patients (69.1% female) and 313 controls (47.3% females). Genomic DNA was extracted from peripheral venous blood, PCR-coamplified for HLA-DRB1 and typed using a reverse line-blot assay. Compared to controls, prevalence of HLA-DRB1*03 (28.1% vs. 15.9%, p=0.01) and HLA-DRB1*04 (25.8% vs. 14.4%, p=0.01) was greater in AG patients, conferring an OR of 2.05 and 2.07, respectively. HLA-DRB1*01 occurred more frequently in controls than in AG patients (11.5% vs. 3.4%, p=0.01) conferring an OR of 0.27. AG patients carrying the HLA-DRB1*03 or *04 alleles were characterised by having more frequently autoimmune thyroid disease (70.4% vs. 42.2%, p=0.01) and intestinal metaplasia (86.4% vs. 62.2%, p=0.01). In our population, over 50% of AG patients carry the HLA-DRB1*03 or *04 alleles associated with autoimmune diseases, suggesting that this subset of AG p...Continue Reading

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Citations

Sep 29, 2011·Current Gastroenterology Reports·Bruno AnnibaleGianfranco Delle Fave
Dec 22, 2010·Clinical Reviews in Allergy & Immunology·Ban-Hock TohFrank Alderuccio
May 16, 2013·World Journal of Gastroenterology : WJG·Daniel DiGiacomoCarolina Ciacci
Oct 14, 2014·Scandinavian Journal of Gastroenterology·Edith LahnerBruno Annibale
Jul 11, 2020·Nature Reviews. Disease Primers·Marco Vincenzo LentiAntonio Di Sabatino
Nov 25, 2020·Microorganisms·Laura ContiEdith Lahner

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