HLA-DRB1*03, but not the TNFA -308 promoter gene polymorphism, confers protection against fistulising Crohn's disease

Immunogenetics
G BoumaA S Peña

Abstract

Crohn's disease (CD) appears in forms so diverse that it has been hypothesized CD might be a syndrome, with different pathogenic mechanisms leading to the various clinical phenotypes. This may plausibly explain the conflicting and inconclusive results with regard to HLA associations in unselected groups of patients. The power of these association studies may increase when disease heterogeneity is taken into account. As fistulising CD has been proposed as a separate subgroup of patients with CD, we studied the carrier frequencies (CF) of the DRB1 alleles in 35 unrelated Caucasian Dutch CD patients with proven peri-anal fistulas. A striking decrease in the frequency of the DRB1(*)03 allele was found in those patients with peri-anal fistulas when compared with a panel of 2400 healthy controls (HC) (3% vs 25%; P = 0.005; Odds Ratio [OR] = 0.09). The DRB1(*)03 allele is in strong linkage disequilibrium with a polymorphism at position -308 in the promoter region of the gene encoding TNFalpha (TNFA-308(*)2). We investigated whether this allele frequency was decreased as well. Surprisingly, the CF of TNFA-308(*)2 was 29%, not different from the CF of 98 HC (34%; P = 0. 7; OR = 0.8). This study is the first showing a significant negativ...Continue Reading

Citations

Jun 26, 2001·Human Immunology·M L LombardiF Castiglione
Jan 8, 2000·Human Immunology·M D'AmatoA Ruffilli
Sep 1, 2000·European Journal of Internal Medicine·A PeraG Rocca
Oct 13, 2006·Current Opinion in Gastroenterology·Jean-Pierre Hugot, Judy H Cho
Jan 1, 2005·Inflammatory Bowel Diseases·Laura FernandezEmilio G de la Concha
Jan 28, 2005·Inflammatory Bowel Diseases·J R Fraser Cummings, Derek P Jewell
Jan 6, 2012·World Journal of Gastroenterology : WJG·Epameinondas V TsianosVasileios E Tsianos
Jan 19, 2012·World Journal of Gastroenterology : WJG·Epameinondas V TsianosVasileios E Tsianos
Feb 5, 1999·Clinical and Experimental Immunology·G BoumaA S Peña
Dec 22, 1999·Clinical and Experimental Immunology·E LouisJ Belaiche
Oct 29, 2009·Immunological Investigations·Sadia RehmanTariq Mehmood
May 6, 2009·Best Practice & Research. Clinical Gastroenterology·Casper G NoomenHerma H Fidder
Oct 31, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Patricia Castro-SantosCarmen Gutierrez
Aug 19, 2003·American Journal of Medical Genetics. Part a·Herma H FidderYehuda Chowers
Feb 27, 2004·Alimentary Pharmacology & Therapeutics·O SchröderJ Stein
May 12, 2010·Alimentary Pharmacology & Therapeutics·Z HanD Fan
Apr 22, 2005·The American Journal of Gastroenterology·Michael J CantorCharles N Bernstein
Sep 14, 2019·Alimentary Pharmacology & Therapeutics·James J AshtonSarah Ennis
May 31, 2001·Alimentary Pharmacology & Therapeutics·T AhmadD P Jewell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.