HLA-DRB1*04:05 in two cases of Vogt-Koyanagi-Harada disease-like uveitis developing from an advanced melanoma patient treated by sequential administration of nivolumab and dabrafenib/trametinib therapy

The Journal of Dermatology
Taku FujimuraSetsuya Aiba

Abstract

Although uveitis is reported as a rare adverse event (AE) associated with dabrafenib/trametinib therapy or nivolumab, the occurrence of severe uveitis is extremely rare. We describe two cases of Vogt-Koyanagi-Harada (VKH)-like uveitis developing after the sequential administration of nivolumab and dabrafenib/trametinib therapy. Interestingly, both cases had HLA-DRB1*04:05, which is strongly associated with VKH disease, and achieved biologically complete remission after the treatment for uveitis. Our cases suggest a possible correlation between VKH-like uveitis as an AE and the clinical outcomes of sequential administration of nivolumab and dabrafenib/trametinib therapy for the treatment of advanced melanoma.

References

Jan 30, 2014·Case Reports in Ophthalmology·Lavnish JoshiSimon R J Taylor
Nov 18, 2014·The New England Journal of Medicine·Caroline RobertPaolo A Ascierto
Jun 17, 2015·Journal of Ophthalmic Inflammation and Infection·Dafina DraganovaFrançois Willermain
Aug 19, 2017·BMC Ophthalmology·Stephanie SarnyYosuf El-Shabrawi
Sep 12, 2017·The New England Journal of Medicine·Jedd D WolchokJames Larkin

❮ Previous
Next ❯

Citations

Sep 18, 2018·Current Opinion in Ophthalmology·Ramana S MoorthyEmmett T Cunningham
Jun 5, 2019·Ocular Immunology and Inflammation·Atitaya ApivatthakakulKessara Pathanapitoon
Aug 15, 2019·The British Journal of Ophthalmology·Arthi Ganesh VenkatSunil Srivastava
Sep 7, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Nataša MihailovicNicole Eter
Mar 2, 2019·Ocular Immunology and Inflammation·Michel M SunLynn K Gordon
Aug 23, 2020·Indian Journal of Ophthalmology·Manisha AgarwalBahram Bodaghi
Sep 20, 2020·Life·Taku FujimuraSetsuya Aiba
Jan 5, 2021·Documenta Ophthalmologica. Advances in Ophthalmology·Hiroko EnomotoMineo Kondo
Jan 14, 2021·Survey of Ophthalmology·Maram E A Abdalla Elsayed, Igor Kozak
Feb 22, 2021·Vestnik oftalmologii·O D OstroumovaL K Moshetova
Apr 1, 2021·Drugs·Blake H FortesLauren A Dalvin
Apr 27, 2021·Expert Opinion on Drug Safety·Janny E LommertsRosalie M Luiten
May 20, 2021·Ocular Immunology and Inflammation·Ryan T YanagiharaSteven S Saraf
Oct 29, 2021·Immunotherapy·Christine FardeauBénédicte Lebrun-Vignes
Jan 9, 2022·Documenta Ophthalmologica. Advances in Ophthalmology·Gyu Eun HwangHoon Dong Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.