HLA-DRB1*1501 risk association in multiple sclerosis may not be related to presentation of myelin epitopes

Journal of Neuroscience Research
Thomas P FinnArthur A Vandenbark

Abstract

Susceptibility to multiple sclerosis (MS) is associated genetically with human leucocyte antigen (HLA) class II alleles, including DRB1*1501, DRB5*0101, and DQB1*0602, and it is possible that these alleles contribute to MS through an enhanced ability to present encephalitogenic myelin peptides to pathogenic T cells. HLA-DRB1*1502, which contains glycine instead of valine at position 86 of the P1 peptide-binding pocket, is apparently not genetically associated with MS. To identify possible differences between these alleles in their antigen-presenting function, we determined if T-cell responses to known DRB1*1501-restricted myelin peptides might be diminished or absent in transgenic (Tg) DRB1*1502-expressing mice. We found that Tg DRB1*1502 mice had moderate to strong T-cell responses to several myelin peptides with favorable DRB1*1501 binding motifs, notably myelin oligodendrocyte glycoprotein (MOG)-35-55 (which was also encephalitogenic), proteolipid protein (PLP)-95-116, and MOG-194-208, as well as other PLP and MOG peptides. These peptides, with the exception of MOG-194-208, were also immunogenic in healthy human donors expressing either DRB1*1502 or DRB1*1501. In contrast, the DRB1*1502 mice had weak or absent responses to p...Continue Reading

References

Feb 1, 1992·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·S W SerjeantsonY L Yu
Sep 6, 1991·Cell·D CosgroveD Mathis
Sep 1, 1994·Nucleic Acids Research·V BrusicL C Harrison
Apr 1, 1996·European Journal of Immunology·L FuggerG Sonderstrup-McDevitt
Aug 1, 1996·Nature Genetics·G C EbersN Risch
Mar 1, 1996·Immunology Letters·S MurakamiY Nishimura
Apr 1, 1997·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·G J StewartB H Bennetts
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·S D PatelG Sonderstrup-McDevitt
Sep 26, 1997·International Archives of Allergy and Immunology·N OhtaK Tanabe
Apr 16, 1998·The Journal of Clinical Investigation·V Taneja, C S David
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M CongiaG Sønderstrup
Oct 23, 1998·The Journal of Experimental Medicine·K J SmithK W Wucherpfennig
Nov 6, 1998·The Journal of Experimental Medicine·R L Ufret-VincentyS Brocke
Jan 13, 2000·Immunological Reviews·G SønderstrupH O McDevitt
Feb 26, 2000·Human Immunology·F Borrás-CuestaJ Lasarte
Feb 15, 2001·Journal of Neuroscience Research·N HellingsP Stinissen
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A ItoH Offner
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T G ForsthuberR Weissert

❮ Previous
Next ❯

Citations

Oct 1, 2011·Translational Stroke Research·Kozaburo AkiyoshiPatricia D Hurn
May 16, 2009·Stroke; a Journal of Cerebral Circulation·Sandhya SubramanianHalina Offner
Jul 5, 2015·Journal of Autoimmunity·Jill A Hollenbach, Jorge R Oksenberg
Mar 4, 2021·Multiple Sclerosis and Related Disorders·Navia VinoyLalitha Biswas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.