PMID: 9442804Jan 27, 1998Paper

HLA-DR/DQ/DP interactions in rheumatoid arthritis

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
C SeidlJ P Kaltwasser

Abstract

Rheumatoid arthritis (RA) is associated with the presence of particular HLA-DRB1 alleles. In order to characterize HLA-DQB1 and/or-DPB1 alleles that contribute to disease susceptibility besides HLA-DRB1 alleles, we have analysed the HLA-DRB1, -DQB1 and -DPB1 polymorphism in 84 RA patients and 135 controls. HLA typing for HLA-DRB1 and -DQB1 alleles was performed using sequence-specific primers in combination with sequence-based typing. HLA-DPB1 alleles were characterized by reverse dot-blot hybridization. Our data confirm the predominant role of the (Q)R/KRAA sequence from AA position 70-74 of the HLA-DRB chain for disease susceptibility. In particular, the lysine (K) substitution at position 71 was highly significantly associated with RA. Analysis of the DQB1 locus revealed no association with RA when linkage disequilibrium between HLA-DRB1 and -DQB1 alleles was considered. In contrast, we observed an increased frequency of HLA-DPB1*0401 among (Q)R/KRAA-positive patients. (Q)R/KRAA-negative RA patients exhibited an overrepresentation of HLA-DPB1*0201 and HLA-DPB1*0601. Rheumatoid factor (RF) production correlated with the presence of the disease-associated (Q)R/KRAA amino acid cassette of the HLA-DRB chain. When HLA-DPB1 allele...Continue Reading

Citations

Mar 10, 2001·Joint, Bone, Spine : Revue Du Rhumatisme·A Perdriger
May 2, 2007·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Rifu XuBang Liu
Feb 14, 2002·Rheumatic Diseases Clinics of North America·Jennifer D Gorman, Lindsey A Criswell
Feb 3, 2004·Journal of Animal Science·H Zhou, J G H Hickford
Apr 14, 2005·Journal of Animal Science·H ZhouQ Fang
Aug 27, 2005·European Journal of Epidemiology·Yogita GhodkeBhushan Patwardhan
Jun 26, 2004·Journal of Animal Science·J G H HickfordQ Fang
Apr 30, 2017·Postgraduate Medical Journal·Jun WuDong-Qing Ye

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