HLA-G does not have a pathophysiological role in Graves' disease

Journal of Clinical Pathology
E H KempA P Weetman

Abstract

It has been suggested that the non-classic HLA class I molecule HLA-G plays a role in autoimmune disease by protecting tissues from damage by infiltrating cytotoxic T cells. Such infiltration occurs in the thyroid of patients with Graves' disease (GD) and Hashimoto's thyroiditis (HT) and can eventually result in tissue destruction. The aim of the current study was to analyse thyroid tissue and thyrocytes obtained from individuals with autoimmune thyroid disease for the expression of HLA-G. HLA-G expression was analysed in thyroid tissue taken from six patients with GD and one with HT by reverse transcriptase polymerase chain reaction. Thyroid tissue samples isolated from six patients with multinodular goitre (MNG) were used as non-autoimmune controls. HLA-G expression was also examined in cultured thyroid follicular cells (TFCs). The expression of HLA-G was not detected in the thyroid gland of patients with either GD, HT, or MNG. Furthermore, HLA-G expression could not be detected in cultured patient TFCs under basal conditions or after stimulation with the proinflammatory cytokines-interleukin 1alpha, interferon gamma, and tumour necrosis factor alpha. HLA-G expression does not occur in the thyroid of patients with GD, indicat...Continue Reading

References

Nov 1, 1985·The Journal of Clinical Endocrinology and Metabolism·A P WeetmanA S Fauci
Aug 1, 1994·The Journal of Clinical Endocrinology and Metabolism·P F WatsonA P Weetman
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·N Rouas-FreissE D Carosella
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·P PaulE D Carosella
Oct 20, 1998·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M J CastroA Arnaiz-Villena
Feb 12, 2000·European Journal of Immunology·A DorlingR I Lechler
Jul 21, 2000·Lancet·N LilaE D Carosella
Sep 21, 2000·Journal of Reproductive Immunology·D R BainbridgeI L Sargent
Sep 21, 2001·The Journal of Investigative Dermatology·K KhosrotehraniS Aractingi
Sep 28, 2001·Trends in Immunology·D BainbridgeI Sargent
Sep 28, 2001·Trends in Immunology·E D CarosellaN Rouas-Freiss

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Citations

Oct 5, 2013·Thyroid : Official Journal of the American Thyroid Association·Nathalie Lobo de Figueiredo FeitosaLéa Maria Zanini Maciel
Dec 25, 2012·Human Immunology·Larissa Mesquita NunesIsabela Jubé Wastowski
Nov 22, 2017·Turkish Journal of Medical Sciences·Murat AkınHasan Bostancı

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