HLA-G expression in gastric carcinoma: clinicopathological correlations and prognostic impact

Virchows Archiv : an International Journal of Pathology
Giuseppe MurdacaRoberto Fiocca

Abstract

To analyze expression of human leukocyte antigen-G (HLA-G) in gastric adenocarcinoma and correlate its expression with histological and clinical variables. A continuous series of 94 unselected patients with gastric adenocarcinoma (stage I to III) were selected. All histological and clinical variables were collected including the intensity of intra- and peri-tumor lymphocytic infiltration. HLA-G expression was investigated using immunohistochemistry. All histological samples analyzed for HLA-G expression were taken from the primary gastric lesion and included non-neoplastic mucosa. Evaluation of HLA-G expression was performed on the transition zone between tumor and non-neoplastic mucosa, and the invasive front of the tumor and assessment was performed as follows: percentage of positive (strong expression vs weak) cells. A variable amount of HLA-G-positive tumor cells was found in 24 out of 94 cases (25.5%). No significant correlation was found between HLA-G expression and other clinicopathological variables (sex, age, stage, grade, histotype). The overall median survival was worse in patients with HLA-G-positive adenocarcinoma (24.3 months, CI95% 7.7-41.0) compared to those with HLA-G-negative tumors (66.3 months, CI95% 53.0-79...Continue Reading

References

Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·N Rouas-FreissE D Carosella
Aug 13, 1998·Immunological Reviews·C A O'Callaghan, J I Bell
Jul 28, 1999·International Immunology·F A Le GalN Rouas-Freiss
Sep 21, 2000·Journal of Reproductive Immunology·D R BainbridgeI L Sargent
Feb 7, 2001·International Immunology·B RiteauN Rouas-Freiss
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·N LilaE D Carosella
Sep 17, 2003·Tissue Antigens·J LeMaoultE D Carosella
Nov 7, 2003·Human Immunology·Yasmine SebtiLaurence Amiot
Jan 8, 2004·Seminars in Cancer Biology·Nathalie Rouas-FreissEdgardo D Carosella
Jan 8, 2004·Seminars in Cancer Biology·Vera RebmannHans Grosse-Wilde
Mar 9, 2005·The Journal of Allergy and Clinical Immunology·Roberta RizzoOlavio R Baricordi
Mar 15, 2006·Gynecologic Oncology·Breton F BarrierEdward R Kost
Jun 15, 2007·Annals of Surgical Oncology·Shang-Mian YieXin-Mei Lin
Aug 4, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shang-mian YieXin-mei Lin
Aug 25, 2007·Seminars in Cancer Biology·Erinn Downs-KellyDonna E Hansel
Sep 11, 2007·Seminars in Cancer Biology·Vito PistoiaSoldano Ferrone
Feb 6, 2008·Trends in Immunology·Edgardo D CarosellaNathalie Rouas-Freiss
Mar 13, 2008·Blood·Edgardo D CarosellaJoel Lemaoult
Nov 11, 2010·Cellular and Molecular Life Sciences : CMLS·Laurence AmiotBarbara Seliger
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Tolga TuncelEmin Gokhan Kandemir
May 7, 2014·Journal of Immunology Research·Nathalie Rouas-FreissEdgardo D Carosella

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Citations

Nov 11, 2018·American Journal of Reproductive Immunology : AJRI·Małgorzata Walentowicz-SadleckaMagdalena Dutsch-Wicherek
Oct 2, 2020·International Journal of Immunogenetics·Antonio Arnaiz-VillenaJose M Martin-Villa
Feb 24, 2020·Stem Cell Reviews and Reports·Bernardo ZoehlerMaria Da Graça Bicalho
Aug 8, 2021·International Journal of Molecular Sciences·Ricky B van de WaterPeter J K Kuppen

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