HLA-G expression in placenta in relation to HLA-G genotype and polymorphisms

American Journal of Reproductive Immunology : AJRI
Thomas Vauvert F HviidMichael Bzorek

Abstract

The expression of the non-classical human leukocyte antigen (HLA) class Ib gene, HLA-G, seems to be important at the feto-maternal interface. The HLA-G molecule is almost monomorphic and expressed in both membrane-bound and soluble isoforms. It has been shown to inhibit natural killer cell -mediated lysis and influence cytokine expression. HLA-G gene polymorphism has been linked to differences in gene expression profile of alternatively spliced HLA-G transcripts and levels of specific HLA-G messenger RNA (mRNA) isoforms. Furthermore, aberrant HLA-G expression has been reported in preeclamptic placentas. On this background it is of general interest to further elucidate any associations between HLA-G polymorphism and protein expression. We have investigated HLA-G protein expression by immunohistochemistry in HLA-G genotyped placentas from term. HLA-G mRNA expression in preeclamptic placentas and in control placentas was also studied by microarray technology. The studies of HLA-G protein expression in term placentas by immunohistochemical analysis showed no clear associations with HLA-G genotypes although this could be because of the very semi-quantitative nature of this technique. However, we found a tendency towards reduction of...Continue Reading

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Citations

Apr 18, 2014·Journal of Immunology Research·Mette DahlThomas Vauvert F Hviid
Mar 14, 2008·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Sandra A FoundsYvette P Conley
Jan 8, 2015·Frontiers in Immunology·Snezana Djurisic, Thomas Vauvert F Hviid
Oct 28, 2008·Molecular Human Reproduction·Shang-mian YieClifford L Librach
Jun 3, 2010·The Journal of International Medical Research·M H KristensenJ Mejer
Apr 17, 2018·Clinical and Experimental Immunology·P ContiniF Puppo
Nov 11, 2005·Human Reproduction Update·Thomas Vauvert F Hviid
Sep 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Mehdi HaghiAbbas Sahebghadam Lotfi
Dec 14, 2017·Molecular Genetics and Genomics : MGG·Aleksandra BylińskaIzabela Nowak
Mar 11, 2006·Clinical Science·Sally Chappell, Linda Morgan

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