PMID: 20120086Feb 3, 2010Paper

HLA-G: from feto-maternal tolerance to organ grafting

Bulletin et mémoires de l'Académie royale de médecine de Belgique
E D Carosella

Abstract

E.D. Carosella was the pioneer who demonstrated the protective role of the HLA-G molecule on trophoblasts, which form a shield protecting the fetus from the immune reaction of its mother and subsequent reject. This non-classical HLA class I molecule is first expressed on the fertilized ovocyte, thus enabling a uterine implantation and then on the surface of the placenta trophoblast where the classical class I and II antigens are absent. He brought the first demonstration ex vivo of the protector role of HLA-G molecule present on the surface of fetal cytotrophoblast cells versus the lysis carried out by maternal decidual uterine NK cells, in both semi-allogenic combinations (maternal uterine NK cells and their own fetal cytotropohoblast counterparts) and allogenic combinations (different maternal uterine NK cells and cytotrophoblasts from different fetuses). The blockage of this protein triggers off an important cytotoxicity towards the fetal cells. Furthermore, he showed that HLA-G molecules act as an inhibitor of the T-lymphocytes, NK cells and antigen presenting cells (APC). Through his discovery Carosella also shows for the first time the three major clinical consequences: I) HLA-G molecules are crucial, as an altered expres...Continue Reading

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
E D Carosella
Proceedings of the National Academy of Sciences of the United States of America
N Rouas-FreissE D Carosella
American Journal of Reproductive Immunology : AJRI
B DaviesA King
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
N Rouas-FreissE D Carosella
© 2021 Meta ULC. All rights reserved