HLA-G polymorphism and transitional cell carcinoma of the bladder in a Brazilian population

Tissue Antigens
E C CastelliE A Donadi

Abstract

The morphologic appearance and clinical behavior of the human urinary bladder papillary transitional cell carcinoma (TCC) probably result from a complex interaction between carcinogenic insults and host resistance during the patient's life. While the main recognized risk factors are of environmental origin (e.g. smoking), relatively little information exists about the susceptibility to TCC development. The human leukocyte antigen G (HLA-G) molecule plays an important role in immune response regulation and has been implicated in the inhibition of the cytolytic function of natural killer and cytotoxic T cells. Several lines of evidence indicate that HLA-G polymorphisms influence the expression level and production of different HLA-G isoforms. The aim of this study was to explore a possible influence of the HLA-G polymorphism on the susceptibility to urinary bladder TCC development and progression in smokers and nonsmokers Brazilian subjects. The HLA-G locus was found to be associated with susceptibility to TCC development and progression. The G*0104 allelic group (specially the G*010404 allele) and the G*0103 allele were associated with a tobacco-dependent influence on TCC development. The G*0104 group was associated with progres...Continue Reading

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Citations

Nov 26, 2010·Cellular and Molecular Life Sciences : CMLS·Eduardo A DonadiPhilippe Moreau
May 31, 2011·Molecular Biology and Evolution·Erick C CastelliEduardo A Donadi
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Jan 19, 2016·Human Immunology·Julieta LazarteDiego Delgado
Jan 21, 2010·Human Immunology·Celso T Mendes-JuniorEduardo A Donadi
Aug 12, 2009·Human Immunology·Erick C CastelliEduardo Antonio Donadi
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Jul 3, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Brunna M AlvesEsmeralda A Soares
Feb 24, 2015·Frontiers in Immunology·Fabrício C DiasEduardo A Donadi
Oct 24, 2014·Frontiers in Immunology·Erick C CastelliCelso T Mendes-Junior
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Oct 2, 2020·International Journal of Immunogenetics·Antonio Arnaiz-VillenaJose M Martin-Villa
Apr 25, 2019·International Journal of Molecular Sciences·Franziska M WürfelWolfgang Würfel

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