PMID: 2492197Jan 1, 1989Paper

HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes

Arthritis and Rheumatism
G T NepomB S Nepom

Abstract

We examined the association of individual HLA genes with rheumatoid arthritis (RA), using oligonucleotide probes that identified both DR4-associated and non-DR4-associated genes. Two distinct HLA-DR beta alleles (Dw4 and Dw14) were found in DR4+ RA patients compared with controls (Dw4 50% versus 17%; Dw14 35% versus 5%; total DR4 73% versus 30%), indicating that these 2 alleles are independent susceptibility genes. Remarkably, the majority of the DR4- RA patients also demonstrated a linear DNA sequence, apparently "shuffled" between different susceptibility alleles, identified with an oligonucleotide probe to a key portion of the Dw14 gene.

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Citations

Dec 17, 2002·Arthritis and Rheumatism·Linda K MyersAndrew H Kang
Dec 4, 1998·Springer Seminars in Immunopathology·A P Cope, G Sønderstrup
Nov 24, 1995·Pharmacy World & Science : PWS·B A t Hart, H G Otten
Sep 1, 1996·Clinical Rheumatology·A UddhammarS Rantapää-Dahlqvist
Jan 1, 1990·Rheumatology International·B LangH H Peter
Jan 1, 1995·Immunologic Research·L I Sakkas, C D Platsoucas
Jan 1, 1994·Immunologic Research·L I SakkasC D Platsoucas
May 9, 2006·Clinical Rheumatology·Mustafa CesurYaşar Karaarslan
Apr 20, 2006·Modern Rheumatology·Kei OhnumaChikao Morimoto
Jan 1, 1992·Molecular Aspects of Medicine·M Baines, A Ebringer
Nov 1, 1991·Human Immunology·E M MickelsonJ A Hansen
Sep 1, 1990·Research in Immunology·J Holoshitz
Apr 1, 1989·Current Opinion in Immunology·R Winchester
Apr 1, 1989·Current Opinion in Immunology·G T Nepom
Dec 1, 1992·Current Opinion in Immunology·P Wordsworth
Feb 1, 1994·Current Opinion in Immunology·F Sinigaglia, J Hammer
Feb 1, 1997·Immunology Today·C WilsonC Ettelaie
Apr 21, 1998·Human Immunology·L E AdamsE V Hess

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