HLA genotyping in pediatric celiac disease patients

Bosnian Journal of Basic Medical Sciences
Biljana StankovićBranka Zukic

Abstract

Celiac disease (CD) is a chronic inflammatory disease in the small intestine triggered by gluten uptake that occurs in genetically susceptible individuals. HLA-DQ2 protein encoded by HLA-DQA1*05 and DQB1*02 alleles is found in 90-95% of CD patients. All of the remaining patients carry HLA-DQ8 protein encoded by HLA-DQA1*03 and DQB1*03:02 alleles. Specific HLA-DQ genotypes define different risk for CD incidence. Presence of susceptible HLA-DQ genotypes does not predict certain disease development, but their absence makes CD very unlikely, close to 100%. Here we presented for the first time the distribution of HLA-DQ genotypes in the group of pediatric celiac patients from the University Children's Hospital, Belgrade, Serbia and estimated risk for CD development that these genotypes confer. Seventy three celiac disease patients and 62 healthy individuals underwent genotyping for DQA1, DQB alleles and DRB1 allele. 94.5% of patients carried alleles that encode DQ2 protein variant and 2.7% carried alleles that encode DQ8 protein variant. Two patients carried single DQB1*02 allele. No patients were negative for all the alleles predisposing to CD. The highest HLA-DQ genotype risk for CD development was found in group of patients homoz...Continue Reading

Citations

Mar 5, 2016·Italian Journal of Pediatrics·Nedeljko RadlovicZorica Stojsic
Nov 12, 2016·Human Genomics·Angeliki BalasopoulouTheodora Katsila
Jan 17, 2017·Pediatric Gastroenterology, Hepatology & Nutrition·Shailja VajpayeeAakash Sharma
Sep 10, 2019·Journal of Digestive Diseases·Abdulrahman Al-HussainiMuhammed Salman Bashir
Apr 2, 2020·Genes·Anna VesninaVictor Atuchin
Aug 9, 2020·BMC Gastroenterology·Nazanin TaraghikhahMohammad Reza Zali

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