PMID: 20630136Jul 16, 2010Paper

HLA haplotype in a patient with systemic lupus erythematosus triggered by hepatitis B vaccine

Clinical Nephrology
D SantoroS Gangemi

Abstract

Find an association between hepatitis B vaccine-related systemic lupus erythematosus and HLA. A 27-year-old woman who developed a lupus nephritis after the administration of hepatitis B vaccine. We studied HLA antigen expression on lymphocytes and genomic haplotype. Class I-II HLA antigen typing was performed by the microlymphocytotoxicity test with the standard NIH method, and Class I-II HLA allele typing by polymerase chain reaction, using single-strand oligonucleotide dot-blot kits. The serological haplotype was HLA A24/25, B18 (Bw6)/-, C-/-, DQ7/-, DR11(5)/52. The genomic haplotype was A*2403/2504, B*1825/1825, C*1207/ 1207, DRB1*1102/1132, DRB3*0202/0202, DQA1*0505/0505, DQB1*0301/0301. Then we sought for analogies with haplotypes known to be related to other systemic AID. Since we have found HLA alleles typical both of systemic lupus erythematosus and Sjogren's syndrome, the persistence of ENA-SSA positivity was highly suspicious for a possible overlap syndrome. Hepatitis B vaccine can potentially trigger both the onset or the exacerbations of several autoimmune disorders, including systemic lupus erythematosus, by reduced immune complex clearance or molecular mimicry. This study represents the first report on the associa...Continue Reading

Citations

Apr 2, 2013·Autoimmunity Reviews·Joerg-Patrick Stübgen
Sep 5, 2013·Autoimmunity Reviews·Joerg-Patrick Stübgen
Jul 22, 2014·Journal of Autoimmunity·Nancy Agmon-LevinYehuda Shoenfeld
Mar 12, 2011·Toxicology Letters·Alexander Batista-DuharteErnesto Oviedo-Orta
Oct 4, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alessandra SorianoYehuda Shoenfeld
Apr 21, 2011·Lupus·R Cervera

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