PMID: 6973559Sep 1, 1980Paper

HLA-linked B cell alloantigens of a new segregant series: population and family studies of the SB antigens

Human Immunology
S ShawA H Johnson

Abstract

In order to define the new human histocompatibility antigens, we have generalized primed lymphocytes using responder and stimulator cells matched for all recognized HLA-linked histocompatibility antigens (A,B,C,D,DR,MB). Many such primed lymphocytes give highly discriminatory proliferative responses specific for antigens which differ between HLA-A,B,C,D,DR, and MB matched restimulating cells. Five distinct antigens have been defined which appear to be part of a single segregant series (designated "SB"). Studies in a DR/GLO recombinant family indicate that the antigens are coded by an HLA-linked gene telomeric to GLO. Family studies of 57 HLA haplotypes provide an estimate of genotype frequency which is 12% or less for four of the SB alleles but approximately 50% for the most common (SB4, which may be a "public: determinant); approximately 25% of haplotypes are blank. Population studies of one of the SB antigens (SB1) suggest that it is in linkage disequilibrium with the SB antigens are part of a highly polymorphic new segregant series of B cell alloantigens encoded by a gene that maps between HLA-B and GLO.

References

Jun 28, 1975·Lancet·P C Doherty, R M Zinkernagel
Dec 1, 1978·The Journal of Experimental Medicine·R TosiD Pressman
Feb 1, 1979·The Journal of Experimental Medicine·C Feighery, P Stastny
Mar 1, 1977·Transplantation Proceedings·B Dupont, A Svejgaard
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D J Charron, H O McDevitt
Jan 1, 1980·The Journal of Experimental Medicine·D A Shackelford, J L Strominger

❮ Previous
Next ❯

Citations

Jan 1, 1981·Immunogenetics·S ShawP L Smith
Dec 1, 1981·Immunogenetics·G PawelecP Wernet
Jun 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·N A BishofP A Donnelly
Jul 1, 1982·Journal of Clinical Immunology·C B Carpenter
Jul 1, 1981·Human Immunology·T MoenE Thorsby
Nov 1, 1984·Human Immunology·N OhtaF H Bach
Sep 1, 1986·Human Immunology·A H JohnsonR J Hartzman
Sep 1, 1990·Human Immunology·T W Sell, D D Eckels
May 1, 1994·Human Immunology·D ChandanayingyongE Rungruang
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M Roux-DossetoJ L Strominger
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J J Hyldig-NielsenA Svejgaard
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D D EckelsJ R Lamb
Oct 25, 1985·Nucleic Acids Research·S K LawranceS M Weissman
Oct 1, 1993·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·W M HowellD G Haegert
Mar 15, 1992·The American Journal of Cardiology·C B GrangerT M Bashore
Mar 1, 1988·Tissue Antigens·J J Hyldig-NielsenA Svejgaard
Dec 15, 2016·Frontiers in Immunology·Rene J Duquesnoy
Jul 3, 1983·Nature·A J WatsonF H Bach
Mar 1, 1982·Tissue Antigens·H E JohnsenF Kissmeyer-Nielsen
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·C M Zmijewski
Jun 6, 2000·Journal of Immunotherapy·M S BradyJ S Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.