HLA linked immune response to S and pre-S2 gene products in hepatitis B vaccination.

Tissue Antigens
M R MarescotP Debre

Abstract

In order to detect a possible HLA linked genetic control of human immune responses to hepatitis B virus, forty healthy adult persons of the same age typed for HLA-A, -B and -DR antigens, were vaccinated against virus hepatitis B and sequentially tested for anti-HBs and anti-pre-S2 antibodies. They received three injections of Hevac-B Pasteur vaccine, the second 1 month and the third 3 months after the first. Following the third immunization, 38 individuals (95%) had a protective level of anti-HBs antibodies and 17 (42.3%) had a positive level of anti-pre-S2 antibodies. HLA-A11 antigen was significantly more frequent (pc = 0.007) among anti-HBs high responders than low responders. In addition, anti-HBs high responders were more frequently HLA-DR1, and less frequently HLA-DR4 and DR7 positive; corrected values, however, were not significant. Anti-pre-S2 high responders showed an apparent increase of HLA-B7, B14 or DR3 antigens, when compared to low responders (pc not significant).

References

Feb 1, 1978·American Journal of Clinical Pathology·P I TerasakiY Iwaki
Jan 1, 1974·Tissue Antigens·A SvejgaardW F Bodmer
Jan 1, 1983·Immunological Reviews·P StastnyG Nunez
Jul 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E L KrawittB R MacPherson
May 1, 1981·Journal of the American Academy of Dermatology·D H WalkerM Valdes-Dapena

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Citations

Dec 1, 1996·Journal of Medical Virology·J N Zuckerman
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S H AhnY M Moon
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K Q HuA Siddiqui
Jul 1, 1995·British Journal of Haematology·C LarcherH P Huemer
Jan 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·K P BouterJ van Hattum

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