HLA-Mismatched Donors in Patients with Myelodysplastic Syndrome: An EBMT Registry Analysis

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Marie RobinNicolaus Kröger

Abstract

Recently, haploidentical transplantation (haplo) using post-transplant cyclophosphamide (PTCy) has been reported to give very encouraging results in patients with hematological malignancies. Patients who have no HLA-matched donor currently have the choice between a mismatched unrelated donor, an unrelated cord blood (CB) donor, and a haploidentical related donor. The aim of our study is to compare the outcome of patients with myelodysplastic syndrome (MDS) who have been transplanted from a haploidentical donor using PTCy, an HLA-mismatched unrelated donor (marrow or peripheral blood stem cells), or an unrelated mismatched CB donor. A total of 833 MDS patients from the European Group for Blood and Marrow Transplantation (EBMT) registry, transplanted between 2011 and 2016, were identified. The potential benefit of haplo was compared with mismatched unrelated and CB donors in an adjusted and weighted model taking into account potential confounders and other prognostic variables. Haplo was at lower risk of acute graft-versus-host disease (GVHD) than mismatched unrelated donor (P = .010) but at similar risk than CB. Progression-free survival was better after haplo (versus mismatched unrelated, P = .056; versus CB, P = .003) and over...Continue Reading

Citations

Feb 8, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giancarlo FatobeneMary Eapen
Mar 7, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Koen W van Besien, Nina Orfali
Aug 18, 2020·International Journal of Hematology·Ming ZhouShunqing Wang
Jul 3, 2019·Japanese Journal of Clinical Oncology·Kittika PoonsombudlertNath Limpruttidham
Dec 7, 2019·Hematology·Guillermo F Sanz
Sep 9, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takaaki KonumaUNKNOWN Adult Myelodysplastic Syndrome Working Group of the Japan Society for Hematopoietic Cell Transplantation
May 29, 2020·Best Practice & Research. Clinical Haematology·Marie Robin, Raphael Itzykson
Jun 10, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ryotaro NakamuraCorey Cutler

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