PMID: 6977179Sep 1, 1981Paper

HLA restriction of dinitrophenyl-specific cell-mediated cytotoxicity in vitro

Scandinavian Journal of Immunology
E DickmeissA Svejgaard

Abstract

Lymphocytes from dinitrochlorobenzene-sensitized individuals can be stimulated in vitro by autologous dinitrophenyl (DNP)-conjugated lymphocytes to produce cytotoxic T lymphocytes (CTLs). The activity of these CTLs is specific for DNP-conjugated target cells, and there is no cross-reaction with nitrosodimethylaniline- or trinitrophenyl-conjugated target cell. Evidence is presented which makes it improbable that the cytotoxicity is caused by an antibody-dependent (ADCC-like) mechanism. Most of the DNP-specific cytotoxicity is restricted by the HLA-ABC antigens of th CTL donor, and there is only a low degree of lysis of DNP-conjugated allogeneic target cells not sharing HLA-ABC antigens with the donor. The CTLs did not lyle non-conjugated allogeneic target cells. When CTLs were tested against allogeneic DNP-conjugated targets sharing only one of the HLA-ABC antigens of the CLT donor, it was seen that the phenomenon of preferential restriction was pronounced; that is, only some of the antigens of the donor were restricting. A certain pattern has emerged: some antigens (e.g. A2) are good restricting antigens, some (e.g. B12) do not restrict, and some (e.g. B5) function well in one donor but not in another. The serologically cross-r...Continue Reading

References

Jun 1, 1978·Transplantation·E GoulmyJ J van Rood
Jan 24, 1979·Medical Microbiology and Immunology·H W KrethG Eckert
Jul 1, 1978·European Journal of Immunology·G S HansenA Svejgaard
Apr 7, 1977·Nature·E GoulmyJ J van Rood
Feb 1, 1979·The Journal of Experimental Medicine·E GoulmyB A Bradley
Mar 1, 1979·The Journal of Experimental Medicine·S Shaw, W E Biddison
Mar 1, 1979·Diabetes Care·M ChristyA Svejgaard
Aug 1, 1975·European Journal of Immunology·W P ZeijlemakerV P Eijsvoogel
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·I S MiskoJ H Pope
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J E ColiganT H Hansen

❮ Previous
Next ❯

Citations

Jan 1, 1985·International Journal of Immunopharmacology·E LanghoffE Dickmeiss

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.