Abstract
On the basis of their serologic cross-reactivity, HLA antigens can be organized into cross-reactive groups or CREG's. We have recently defined immunochemically two public alloantigenic determinants X and Y which can account for the serological cross-reactivity of the B7-CREG and B5-CREG, respectively. One of the smaller of these CREG's consists of HLA-B15 and B17. Using microcytotoxicity testing, a fluoresceinated Protein A binding assay, and chemical immunoprecipitation techniques, we have defined a new public alloantigenic determinant, tentatively designated "Z," which is present on the 44,000 dalton glycoprotein chains of HLA-B15 and HLA-B17, but distinct from the B15 and B17 determinants. Since HLA-B15 is also a member of the B5-CREG, and therefore bears allodeterminant Y, this report constitutes the first immunochemical demonstration of two public determinants, Y and Z, on a single HLA-B molecule, HLA-B15.
References
Mar 1, 1976·The Journal of Experimental Medicine·B D SchwartzE M Shevach
Nov 1, 1976·European Journal of Immunology·J Ayres, P Cresswell
Oct 1, 1979·The Journal of Clinical Investigation·B D SchwartzG E Rodey
Dec 1, 1979·The Journal of Experimental Medicine·M LipinskiM Fellous
Apr 7, 1977·Nature·E GoulmyJ J van Rood
Dec 1, 1977·European Journal of Immunology
Dec 1, 1978·The Journal of Experimental Medicine·A McMichael
Dec 8, 1977·Nature·A J McMichaelB A Askonas
Jan 1, 1974·Scandinavian Journal of Immunology·G DorvalH Wigzell
Oct 1, 1972·European Journal of Immunology·V P EijsvoogelP T Schellekens
Feb 1, 1972·Journal of Medical Microbiology·H HaasT Sacks
May 26, 1972·Biochemical and Biophysical Research Communications·M J Hayman, M J Crumpton
Jun 1, 1971·Biochimica Et Biophysica Acta·T K Ray, G V Marinetti
Aug 15, 1970·Nature·U K Laemmli
Nov 1, 1968·Transplantation·K K MittalP I Terasaki
Jan 1, 1980·The Journal of Experimental Medicine·S ShawW E Biddison
Jul 1, 1980·Human Immunology·B D SchwartzG E Rodey
Sep 1, 1980·Human Immunology·A J McMichaelF Brodsky
Sep 1, 1980·Human Immunology·P Parham, J McLean
Sep 1, 1963·The Journal of Clinical Investigation·J J VAN ROOD, A VAN LEEUWEN
Jan 1, 1964·Cold Spring Harbor Symposia on Quantitative Biology·R PAYNEJ BODMER
Citations
Dec 1, 1982·Human Immunology·C MüllerP Wernet
Feb 1, 1985·Human Immunology·C A Keever, E R Heise
Jan 1, 1986·Human Immunology·P ParhamF E Ward
Jul 1, 1990·Human Immunology·A A FullerT C Fuller
Mar 27, 1997·Transplantation·G E RodeyT C Fuller
Apr 6, 2017·HLA : Immune Response Genetics·C S M KramerF H J Claas
Jan 5, 2007·Blood·Judith A WadeCraig Kollman
Apr 1, 1983·Tissue Antigens·C Darke
Mar 1, 1984·Tissue Antigens·C Darke
Mar 1, 1984·Tissue Antigens·H M GebelG E Rodey
Jul 1, 1983·Tissue Antigens·J W OldfatherG E Rodey
Jul 9, 2014·Transplantation·Anat R TamburJoseph R Leventhal
Apr 1, 1985·Tissue Antigens·C Darke
May 1, 1987·Tissue Antigens·T HansenK Hannestad