PMID: 863128Jun 1, 1977Paper

HLA system in Japnaese patients with diabetes mellitus

Diabetes
A KawaY Kono

Abstract

Seventy-eight Japanese diabetics were HLA-typed, with special reference to age at onset, insulin dependency, and family history. HLA-A9, B5, and BW40 were increased, but A1, A3, and B8, which are found frequently among Caucasians, were almost absent among Japanese healthy controls as well as diabetics. J-1, a Japanese specific subclass of BW22, was significantly increased in juvenile-onset diabetics as compared with controls or diabetics with late onset. J-1 was also increased in the diabetics with insulin dependency and/or positive family history. But the association of J-1 with juvenile-onset diabetes mellitus was found to be the strongest. A tendency to a decrease in B5 was also observed in Japanese diabetics with juvenile onset, but this did not reach statistical significance as far as corrected P was concerned. These results showed that genetic markers for diabetes mellitus, especially that with juvenile onset, were different among Japanese from those found among Caucasians. There is ample evidence to indicate a race specificity in HLA phenotypes in diabetics as well as in controls. These findings also strongly suggest that juvenile-onset diabetes mellitus is a disease entity in itself and different from late-onset diabete...Continue Reading

Citations

Oct 11, 1979·The New England Journal of Medicine·G E RodeyJ V Santiago
May 26, 1998·Australasian Radiology·P NgP Despas
Jan 1, 1980·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·N E Simpson
Mar 1, 1984·Rinsho byori. The Japanese journal of clinical pathology·M Kasahara
Mar 1, 1980·Tissue Antigens·M G Hammond, A C Asmal
Oct 1, 1987·Diabetes/metabolism Reviews·A LernmarkG Sundkvist
Sep 1, 1978·Tissue Antigens·N R FaridW H Marshall
Aug 1, 1980·Diabetologia·M G HammondM A Omar

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