HLA typing in acute optic neuritis. Relation to multiple sclerosis and magnetic resonance imaging findings

Archives of Neurology
J L FrederiksenA Svejgaard

Abstract

To study the association of brain magnetic resonance imaging (MRI) findings and HLA findings to clarify the relationship between monosymptomatic optic neuritis (ON) and ON as part of clinically definite multiple sclerosis (CDMS). Population-based cohort of patients with ON referred prospectively during 6 years by neurologists and ophthalmologists within 4 weeks of onset of ON. Referral center in the general community of greater Copenhagen (Denmark) (population, 1.5 million). A consecutive sample of 199 patients aged 12 to 59 years with ON (133 with idiopathic ON, 66 with ON + CDMS), ethnically matched with 192 healthy volunteers. Relation between the HLA-DR15, -DR17, -DQA-1B, and -DQB-1B polymorphisms as defined by restriction fragment length polymorphism analysis, and presence of plaques on T2-weighted brain MRI. The frequency of HLA-DR15 was significantly increased in patients with ON + CDMS (52%) and ON (47%) compared with control subjects (31%). The frequency of HLA-DR17 was almost equal in the ON + CDMS (18%), ON (23%), and control (23%) groups. The frequencies of HLA-DQA-1B (55% in ON + CDMS, 58% in ON) and HLA-DQB-1B (49% in ON + CDMS, 59% in ON) were significantly increased compared with control subjects (41%, HLA-DQA-1...Continue Reading

Citations

Jun 14, 2000·Tissue Antigens·F SellebjergA Svejgaard
Mar 3, 2007·American Journal of Epidemiology·Hollie SchmidtAllison Ashley-Koch
Mar 4, 1998·Current Opinion in Neurology·E P O'Sullivan, C Kennard
Feb 6, 2008·Emergency Medicine Clinics of North America·Michael Vortmann, Jeffrey I Schneider

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