HLAMatchmaker-defined triplet matching is not associated with better survival rates of patients with class I HLA allele mismatched hematopoietic cell transplants from unrelated donors.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
René J DuquesnoyMachteld Oudshoorn

Abstract

This report addresses the concept that permissible HLA mismatching, that is, mismatches that do not generate an allogeneic response, in hematopoietic stem cell transplantation (HCT) can be determined with structural similarity of polymorphic regions. We have applied the triplet version of a structural algorithm called HLAMatchmaker, which considers short sequences involving polymorphic amino acid residues on the molecular surface as key elements of immunogenic epitopes. The triplet matching effect was analyzed in a National Marrow Donor Program dataset consisting of 744 unrelated hematopoietic cell transplantation cases with 1 HLA-A, -B, or -C mismatch and 1690 fully HLA-A, -B, -C, -DR, or -DQ allele matched cases. In multivariate models adjusting for other significant clinical risk factors, the degree of triplet mismatching did not significantly correlate with patient survival, engraftment, or acute graft-versus-host disease (aGVHD). Other structurally based strategies should be pursued to identify permissible HLA mismatches in HCT.

References

Dec 27, 1990·The New England Journal of Medicine·K FleischhauerS Y Yang
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T J Elliott, H N Eisen
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·Q R FanD C Wiley
Dec 26, 2001·The New England Journal of Medicine·E W PetersdorfC Anasetti
Jun 1, 2002·Human Immunology·Katia GagneJean Denis Bignon
Jun 15, 2004·Bone Marrow Transplantation·B E ShawS G E Marsh
Apr 21, 2007·Tissue Antigens·E W PetersdorfUNKNOWN International Histocompatibility Working Group in Hematopoietic Cell Transplantation

❮ Previous
Next ❯

Citations

May 29, 2014·Journal of Immunology Research·Kirsten GeneugelijkEric Spierings
Apr 29, 2014·Transplant Immunology·René J Duquesnoy
Jul 29, 2008·Current Opinion in Immunology·René J Duquesnoy
Oct 4, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stephen SpellmanCarolyn Hurley
Feb 8, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Medhat AskarJaroslaw Maciejewski
Jul 11, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Lee Ann Baxter-LoweCarolyn Katovich Hurley
May 19, 2012·Blood·Stephen R SpellmanUNKNOWN Center for International Blood and Marrow Transplant Research
Jan 11, 2014·Blood·Marcelo A Fernandez-ViñaMichelle Setterholm
Jan 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monique M JörisFrans H J Claas
Jul 26, 2018·Blood Advances·Esteban Arrieta-BolañosStephen R Spellman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.