HMDD v3.0: a database for experimentally supported human microRNA-disease associations

Nucleic Acids Research
Zhou HuangQinghua Cui

Abstract

Comprehensive databases of microRNA-disease associations are continuously demanded in biomedical researches. The recently launched version 3.0 of Human MicroRNA Disease Database (HMDD v3.0) manually collects a significant number of miRNA-disease association entries from literature. Comparing to HMDD v2.0, this new version contains 2-fold more entries. Besides, the associations have been more accurately classified based on literature-derived evidence code, which results in six generalized categories (genetics, epigenetics, target, circulation, tissue and other) covering 20 types of detailed evidence code. Furthermore, we added new functionalities like network visualization on the web interface. To exemplify the utility of the database, we compared the disease spectrum width of miRNAs (DSW) and the miRNA spectrum width of human diseases (MSW) between version 3.0 and 2.0 of HMDD. HMDD is freely accessible at http://www.cuilab.cn/hmdd. With accumulating evidence of miRNA-disease associations, HMDD database will keep on growing in the future.

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Citations

Feb 5, 2019·Briefings in Bioinformatics·Xin QiBairong Shen
Jan 17, 2020·Database : the Journal of Biological Databases and Curation·Rongrong WuBairong Shen
Feb 1, 2020·Briefings in Bioinformatics·Saidi WangHaiyan Hu
May 8, 2020·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tominori Kimura
Jul 1, 2020·Acta Biochimica Et Biophysica Sinica·Lin KangYong Zhang
Oct 1, 2019·Briefings in Bioinformatics·Pingjian DingChee-Keong Kwoh
Jul 30, 2020·International Journal of Molecular Sciences·Marta GerasymchukIgor Kovalchuk
Mar 25, 2020·Aging·Jack KellyXinzhong Li
Aug 25, 2020·Nucleic Acids Research·Lin NingDong Wang
Sep 26, 2020·Chemical Society Reviews·Samantha M MeyerMatthew D Disney
Sep 15, 2020·Journal of Alzheimer's Disease : JAD·Hui Xu, Jianping Jia
Feb 23, 2020·Frontiers in Genetics·Lihong PengLiqian Zhou
Aug 23, 2020·International Journal of Molecular Sciences·Anna Maria GrimaldiMariarosaria Incoronato
Oct 28, 2019·Nucleic Acids Research·Hsi-Yuan HuangHsien-Da Huang
Sep 6, 2019·Molecular Medicine Reports·Taís Silveira AssmannJosé Alfredo Martínez
Apr 23, 2020·International Journal of Molecular Medicine·Jianghuai JiDongguo Li

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Software Mentioned

miRWalk
DisGeNET
HMDD
TAM
SQLite

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