PMID: 16503864Mar 1, 2006Paper

HMG-CoA reductase inhibitors: effects on chronic subacute inflammation and onset of atherosclerosis induced by dietary cholesterol

Current Drug Targets. Cardiovascular & Haematological Disorders
R Kleemann, T Kooistra

Abstract

Besides classical risk factors such as hypercholesterolemia and hypertension, chronic subacute inflammation has recently been recognized as an important force driving the development of atherosclerosis, the most common underlying cause of myocardial infarction and stroke. There is compelling evidence that a disturbance of cholesterol homeostasis contributes to the development of a chronic inflammatory state and that inhibitors of HMG-CoA reductase (statins) may dampen inappropriate inflammatory responses. We review the evidence and suggest mechanisms by which dietary cholesterol can induce an atherogenic inflammatory response in liver and vessel wall, with particular emphasis on the time course of this inflammatory response during atherogenesis and the interplay between these tissues. We discuss how statins interfere in this process, and whether they may reduce chronic subacute inflammation via a) their cholesterol-lowering effect, and/or b) their cholesterol-independent (pleiotropic) vasculoprotective activities. Recent studies performed in (humanized) animal models allow us to distinguish the lipid-lowering-dependent from the lipid-lowering-independent functions of statins. Using these data, we discuss the degree to which the...Continue Reading

Citations

Mar 28, 2008·Current Atherosclerosis Reports·J David Orr
Mar 8, 2007·Bioscience, Biotechnology, and Biochemistry·Kenji MatsumotoShin-ichiro Yokoyama
Mar 10, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Christine Boesch-SaadatmandiGerald Rimbach
Nov 17, 2009·Journal of Ethnopharmacology·Jonatas Zeni KlafkePaulo Ricardo Nazário Viecili
May 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Karuppasamy VenkadeswaranPitchairaj Geraldine
Mar 27, 2018·Expert Review of Respiratory Medicine·Amir A Zeki, Mona Elbadawi-Sidhu
Dec 5, 2006·Biological & Pharmaceutical Bulletin·Kenji MatsumotoShin-ichiro Yokoyama
Sep 16, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carla Maiara Lopes CardozoKarine de Cássia Freitas
Feb 17, 2017·Medicine·Mohsen MazidiAndre Pascal Kengne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.