HMGA2 is confirmed to be associated with human adult height.

Annals of Human Genetics
Tie-Lin YangHong-Wen Deng

Abstract

Recent genome-wide association studies have identified a novel polymorphism, rs1042725, in the HMGA2 gene for human adult height, a highly heritable complex trait. Replications in independent populations are needed to evaluate a positive finding and determine its generality. Thus, we performed a replication study to examine the associations between polymorphisms in HMGA2 and adult height in two US Caucasian populations (an unrelated sample of 998 subjects and a family-based sample of 8385 subjects) and a Chinese population (1638 unrelated Han subjects). We confirmed the association between rs1042725 in HMGA2 and adult height both in the unrelated and family-based Caucasian populations (overall P= 4.25 x 10(-9)). Another two SNPs (rs7968902 and rs7968682), which were in high linkage disequilibrium with rs1042725, also achieved the significance level in both Caucasian populations (overall P= 6.34 x 10(-7), and 2.72 x 10(-9), respectively). Our results provide strong support to the initial finding. Moreover, SNP rs1042725 was firstly found to be associated with adult height (P= 0.008) in the Chinese population, and the effect is in the same direction as in the Caucasian populations, suggesting that it is a common variant across di...Continue Reading

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Citations

Dec 8, 2015·Genome Biology and Evolution·Adiljan KaderYuehui Ma
Aug 16, 2014·PloS One·Maria-Ines FarielloSimon Boitard
Oct 24, 2017·Asian-Australasian Journal of Animal Sciences·Jianping QuanJie Yang
Jun 1, 2015·Zdravstveno Varstvo·Tinka HovnikKatarina Trebušak Podkrajšek
Jan 23, 2019·Journal of Veterinary Internal Medicine·Elaine M NortonMolly E McCue
Jan 23, 2020·International Journal of Molecular Sciences·Robert Vignali, Silvia Marracci
Jun 8, 2011·Menopause : the Journal of the North American Menopause Society·Lin ZhaoGuang Ning
Dec 26, 2018·Frontiers in Genetics·Tamíris Sayuri AguiarYuri Tani Utsunomiya
Apr 15, 2014·Biology Open·Antonella FedericoAlfredo Fusco
Dec 21, 2021·Frontiers in Genetics·Abdessamad OuhrouchBadr Benjelloun

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