HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect

Cell Death & Disease
Sijia HeQian Huang

Abstract

Tumor repopulation during therapy is an important cause of treatment failure. Strategies to overcome repopulation are arising in parallel with advances in the comprehension of underlying biological mechanisms. Here, we reveal a new mechanism by which high mobility group box 1 (HMGB1) released by dying cells during radiotherapy or chemotherapy could stimulate living tumor cell proliferationInhibition or genetic ablation of HMGB1 suppressed tumor cell proliferation. This effect was due to binding of HMGB1with the member receptor for advanced glycation end-products (RAGE), which activated downstream ERK and p38 signaling pathway and promoted cell proliferation. Furthermore, higher HMGB1 expression in tumor tissue correlated with poor overall survival and higher HMGB1 concentration was detected in serum of patients who accepted radiotherapy. Collectively, the results from this study suggested that interaction between dead cells and surviving cells might influence the fate of tumor. HMGB1 could be a novel tumor promoter with therapeutic and prognostic relevance in cancers.

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Citations

Jan 25, 2019·Current Pharmaceutical Design·Gina MandaAntonio Cuadrado
Jul 20, 2019·Allergy·Md Ashik UllahSimon Phipps
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Methods Mentioned

BETA
glycosylation
flow cytometry
co-IP
ELISA
X-ray
transfection

Software Mentioned

GEPIA
GEPIA ( Gene Expression Profiling Interactive Analysis )

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