HMGB1/IL-1β complexes regulate neuroimmune responses in alcoholism

Brain, Behavior, and Immunity
Leon G ColemanFulton T Crews

Abstract

Neuroimmune activation is a key feature of the pathologies of numerous psychiatric disorders including alcoholism, depression, and anxiety. Both HMGB1 and IL-1β have been implicated in brain disorders. Previous studies find HMGB1 andIL-1β form heterocomplexes in vitro with enhanced immune responses, lead to our hypothesis that HMGB1 and IL-1β heterocomplexes formed in vivo to contribute to the pathology of alcoholism. HMGB1/IL-1β heterocomplexes were prepared in vitro and found to potentiate IL-1β receptor proinflammatory gene induction compared to IL-1β alone in hippocampal brain slice culture. These HMGB1/IL-1β complexes were found to be increased in post-mortem human alcoholic hippocampus by co-immunoprecipiation. In mice, acute binge ethanol induced both HMGB1 and IL-1β in the brain and plasma. HMGB1 and IL-1β complexes were found only in mouse brain, with confocal microscopy revealing an ethanol-induced HMGB1 and IL-1β cytoplasmic co-localization. Surprisingly, IL-1β was found primarily in neurons. Studies in hippocampal brain slice culture found ethanol increased HMGB1/IL-1β complexes in the media. These studies suggest a novel neuroimmune mechanism in the pathology of alcoholism. Immunogenic HMGB1/IL-1β complexes represe...Continue Reading

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Citations

May 6, 2019·Addiction Biology·Shuang-Qi GaoJian-Guo Chen
Nov 30, 2019·Alcoholism, Clinical and Experimental Research·A Leslie MorrowPatrizia Porcu
Dec 20, 2019·Alcoholism, Clinical and Experimental Research·Patrick P LoweGyongyi Szabo
Jan 29, 2019·Frontiers in Molecular Neuroscience·Laura OrioBorja García-Bueno
Nov 2, 2019·Biomedit︠s︡inskai︠a︡ khimii︠a︡·M I AirapetovP D Shabanov
Feb 11, 2020·Frontiers in Psychiatry·Jing QiShao-Qing Ju
Jan 20, 2020·Journal of Neuroinflammation·Leon G ColemanFulton T Crews
Nov 10, 2020·Alcoholism, Clinical and Experimental Research·Hui Peng, Kimberly Nixon
Oct 23, 2019·Respiratory Physiology & Neurobiology·Kun-Ming WuYu Ru Kou
Mar 2, 2021·Biomedit︠s︡inskai︠a︡ khimii︠a︡·M I AirapetovP D Shabanov
Feb 22, 2021·Journal of Neuroscience Research·Fulton T CrewsLeon G Coleman
Feb 15, 2021·Alcoholism, Clinical and Experimental Research·Wenfei HuangSulie L Chang
Mar 12, 2021·The American Journal of Chinese Medicine·Liu-Lin XiongXin-Fu Zhou
Apr 4, 2021·International Journal of Molecular Sciences·Liya QinLeon G Coleman
Jun 18, 2021·Disease Models & Mechanisms·Karen E BoschenScott E Parnell
Sep 7, 2021·Alcoholism, Clinical and Experimental Research·Jennifer K MelbourneKimberly Nixon
Nov 28, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Reesha R PatelMarisa Roberto
Dec 30, 2021·Biomedit︠s︡inskai︠a︡ khimii︠a︡·M I AirapetovP D Shabanov

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