HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer

Cell Communication and Signaling : CCS
Deyuan FuChuanli Ren

Abstract

High-mobility group box 2 (HMGB2) is implicated in tumorigenesis in various cancers. However, the clinical significance of HMGB2 signaling in human breast cancer progression remains unknown. We investigated HMGB2 expression in 185 cases of primary breast cancer and matched normal breast tissue specimens, and explored the underlying mechanisms of altered HMGB2 expression as well as the impact of this altered expression on breast cancer growth and on aerobic glycolysis using in vitro and animal models of breast cancer. HMGB2 was more highly expressed in tumor-cell nuclei of breast cancer cells than in the adjacent normal breast tissues (P < 0.05). Higher HMGB2 expression correlated with larger tumor size (P = 0.003) and advanced tumor stage (P = 0.033). A Cox proportional hazards model revealed that HMGB2 expression was an independent prognostic factor for breast cancer after radical resection (P < 0.05). Experimentally, knockdown of HMGB2 expression by stable transfected shRNA significantly decreased the growth and glycolysis of breast cancer cells both in vitro and in mouse models. Mechanically, promotion of breast cancer progression by HMGB2 directly and significantly correlated with activation of LDHB expression and inactivat...Continue Reading

References

Jun 1, 1995·Genes & Development·B M ShykindP A Sharp
Aug 20, 2003·Molecular Biology of the Cell·Coralie PallierVincent Marechal
Feb 24, 1956·Science·O WARBURG
Apr 2, 2005·Nature Reviews. Immunology·Michael T Lotze, Kevin J Tracey
Dec 16, 2006·Trends in Cell Biology·Robert HockMichael Bustin
Feb 17, 2007·The FEBS Journal·Rafael Moreno-SánchezEmma Saavedra
Jan 15, 2009·Nature Reviews. Cancer·Nicholas C Denko
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Feb 4, 2010·Biochimica Et Biophysica Acta·Michal Stros
Feb 26, 2010·Nutrition & Metabolism·Thomas N Seyfried, Laura M Shelton
Sep 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jung-Hee KwonKwan Yong Choi
Nov 30, 2012·Cancer Biology & Therapy·Yi Zhang, Jin-Ming Yang
Mar 14, 2013·International Journal of Cancer. Journal International Du Cancer·Alaa M AliPaul D Pharoah
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Jan 31, 2015·Archives of Pharmacal Research·Yong Hoon ChaNam Hee Kim
Oct 3, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xuexiang YingPingqing He
Nov 7, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Da-Wei SunJin-Hai Tang
Jul 13, 2016·Molecular Cancer Research : MCR·Qingguo LiSanjun Cai
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Apr 27, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Saeedeh Keyvani-GhamsariMaryam Shahhoseini
May 31, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Qingguo LiSanjun Cai

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Citations

Nov 16, 2018·Molecular Oncology·Christiane KlecMartin Pichler
Oct 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martin KučírekMichal Štros
Oct 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shuning WangCun Zhang
Feb 23, 2020·Nature Communications·Samantha D PraktiknjoNikolaus Rajewsky
Nov 14, 2018·Journal of Experimental & Clinical Cancer Research : CR·Mengyu FengYupei Zhao
May 1, 2019·International Journal of Molecular Sciences·Kaja Urbańska, Arkadiusz Orzechowski
Mar 11, 2020·Cancer Research·Anirban Mukherjee, Karen M Vasquez
Nov 24, 2020·Therapeutic Advances in Medical Oncology·Liaoran NiuDaiming Fan
May 8, 2021·Frontiers in Genetics·Diana García-CortésJesús Espinal-Enríquez
Oct 19, 2020·Experimental Cell Research·W ZhangM A Barbieri
Nov 3, 2021·Nature Communications·Miranda V HunterRichard M White
Nov 16, 2021·Frontiers in Genetics·Tong LinLisheng Peng
Jan 14, 2022·Histochemistry and Cell Biology·Yu YamagumaYoshitaka Hishikawa

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Methods Mentioned

BETA
surgical resection
PCR
electrophoresis
Assay

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